Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | THZ531 | 0.264094355 | -0.3101 | 0.1622 | 0.2933 | -0.2919 | 4.3814 | 0.9206 | 1.75e-14 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| HCC38 | AZD2014 | 0.444460248 | 0.1801 | 0.4094 | 63.7169 | -1.0000 | 0.2213 | 0.8924 | 7.9e-13 |
| HCC38 | AZD5363 | 643.6614856 | 0.6677 | 0.0823 | 596.8802 | 0.0105 | 0.2802 | 0.4663 | 0.000390093 |
| HCC38 | AZD6738 | 2.069548926 | -0.2338 | 0.2316 | 6.8694 | -1.0000 | 0.9157 | 0.9405 | 4.44e-16 |
| HCC38 | BMS-265246 | 0.00394749 | -0.0214 | 0.7767 | 0.0054 | -0.0686 | 0.4043 | 0.9575 | 1.11e-16 |
| HCC38 | Ulixertinib | 4.626845935 | 0.3500 | 0.2125 | 206.4527 | -1.0000 | 0.2892 | 0.7494 | 3.07e-08 |
| HCC38 | Alvocidib | 0.139603749 | -0.4046 | 0.2799 | 0.3955 | -0.9001 | 0.9887 | 0.9746 | 1.11e-16 |
| HCC38 | GSK2334470 | 362.2276812 | 0.7326 | 0.0411 | 1000.0000 | -0.2309 | 0.3738 | 0.3294 | 0.006774661 |
| HCC38 | Ribociclib | 0.517768611 | 0.2321 | 0.4237 | 305.2273 | -1.0000 | 0.1722 | 0.8460 | 6.98e-11 |
| HCC38 | LY3023414 | 0.003293109 | -0.0192 | 0.6632 | 57.0896 | -0.9609 | 0.1099 | 0.8238 | 3.77e-10 |
| HCC38 | RO-3306 | 7.435051917 | -0.2110 | 0.0493 | 9.2621 | -1.0000 | 5.0000 | 0.9513 | 1.11e-16 |
| HCC38 | Rucaparib | 3274.321387 | 0.6293 | 0.1296 | 1000.0000 | 0.1004 | 0.1890 | 0.3579 | 0.003936714 |
| HCC38 | Senexin B | 15.63810324 | 0.5236 | 0.1411 | 269.9088 | -0.9985 | 0.3853 | 0.5885 | 1.51e-05 |
| HCC38 | SHP099 | 37.96041806 | 0.4903 | 0.1469 | 730.5570 | -0.5486 | 0.2504 | 0.5746 | 2.29e-05 |
| HCC38 | THZ1 | 0.02382594 | -0.5420 | 0.5167 | 0.0405 | -0.4828 | 1.2756 | 0.9829 | 1.11e-16 |
| HCC38 | THZ531 | 0.179180276 | -0.3210 | 0.1885 | 0.2224 | -0.3480 | 2.4453 | 0.9711 | 1.11e-16 |
| Hs 578T | MK 1775 | 0.014507078 | -0.3462 | 0.7648 | 0.0762 | -0.4564 | 0.3909 | 0.9740 | 1.11e-16 |
| Hs 578T | AZD2014 | 0.068067431 | 0.2555 | 0.5090 | 0.0201 | 0.1834 | 0.3744 | 0.9704 | 1.11e-16 |
| Hs 578T | AZD5363 | 4.921732237 | 0.3377 | 0.2434 | 303.2684 | -1.0000 | 0.2666 | 0.9123 | 6.16e-14 |
| Hs 578T | AZD6738 | 5.182870146 | -0.0390 | 0.0818 | 10.0001 | -1.0000 | 1.6716 | 0.9755 | 1.11e-16 |
| Hs 578T | BMS-265246 | -inf | |||||||
| Hs 578T | Ulixertinib | 1.12758771 | 0.2421 | 0.3284 | 1.7251 | -0.0883 | 0.3825 | 0.9567 | 1.11e-16 |
| Hs 578T | Alvocidib | 0.148558558 | -0.2518 | 0.2560 | 0.2079 | -0.3548 | 1.5955 | 0.9912 | 1.11e-16 |
| Hs 578T | GSK2334470 | 19.04682987 | 0.5381 | 0.1513 | 619.2531 | -1.0000 | 0.3155 | 0.9434 | 2.22e-16 |