Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| T47D | LY3023414 | 0.000116934 | -0.3084 | 0.9068 | 0.4558 | -1.0000 | 0.1329 | 0.9366 | 1.11e-15 |
| T47D | RO-3306 | 7.208767727 | -0.0474 | 0.1168 | 9.9142 | -1.0000 | 3.4475 | 0.8495 | 5.24e-11 |
| T47D | Rucaparib | inf | 0.8130 | 0.0415 | 0.0000 | 0.9307 | 0.0100 | 0.0000 | 0.073451061 |
| T47D | Senexin B | 1.2300495 | 0.1684 | 0.3222 | 54.5356 | -1.0000 | 0.2897 | 0.9170 | 3.08e-14 |
| T47D | SHP099 | inf | 0.6931 | -0.0080 | 0.0000 | 0.9839 | 0.0100 | 0.0000 | 0.180531821 |
| T47D | THZ1 | 0.02898118 | -0.2718 | 0.4598 | 0.0353 | -0.2278 | 1.8920 | 0.9732 | 1.11e-16 |
| T47D | THZ531 | 0.113575449 | -0.1534 | 0.2161 | 0.1189 | -0.1295 | 5.0000 | 0.9624 | 1.11e-16 |
| BT-20 | MK 1775 | 1.80498033053 | -0.6583 | 0.2015 | 4.1869 | -1.0000 | 1.3057 | 0.9322 | 2.44249065418e-15 |
| BT-20 | AZD2014 | 0.129099948542 | 0.1187 | 0.4911 | 0.6794 | -0.2850 | 0.2716 | 0.8667 | 1.14693810005e-11 |
| BT-20 | AZD5363 | 1.72900360981 | 0.1717 | 0.3013 | 86.6237 | -1.0000 | 0.2807 | 0.8604 | 2.05393480002e-11 |
| BT-20 | AZD6738 | 5.68190940846 | 0.1069 | -0.0571 | 5.4098 | 0.1088 | 5.0000 | 0.8298 | 2.43821740575e-10 |
| BT-20 | BMS-265246 | 0.0017956253308 | -0.0805 | 0.8520 | 0.0041 | -0.1756 | 0.3616 | 0.9532 | 1.11022302463e-16 |
| BT-20 | Ulixertinib | 11.8069404762 | 0.3655 | 0.1384 | 160.1062 | -1.0000 | 0.4214 | 0.7256 | 9.53864038866e-08 |
| BT-20 | Alvocidib | 0.109020751309 | -0.6023 | 0.3436 | 0.2983 | -1.0000 | 1.0915 | 0.9859 | 1.11022302463e-16 |
| BT-20 | GSK2334470 | 13.6041849907 | 0.6953 | 0.0817 | 27.5398 | -0.9501 | 1.5098 | 0.3727 | 0.00293794501251 |
| BT-20 | Ribociclib | 0.364051568488 | 0.0541 | 0.4406 | 65.2706 | -1.0000 | 0.2117 | 0.8623 | 1.72427627732e-11 |
| BT-20 | LY3023414 | 0.00529380398207 | -0.6210 | 0.7635 | 0.9065 | -1.0000 | 0.2136 | 0.7707 | 1.01291124377e-08 |
| BT-20 | RO-3306 | 5.05230087025 | -0.2878 | 0.1099 | 5.5833 | -0.3241 | 5.0000 | 0.9562 | 1.11022302463e-16 |
| BT-20 | Rucaparib | inf | 0.8576 | 0.0858 | 0.0000 | 0.9228 | 0.0100 | 0.0000 | 1.0 |
| BT-20 | SHP099 | inf | 0.8790 | 0.0132 | 0.0000 | 0.9876 | 0.0100 | 0.0000 | 0.0930371400466 |
| BT-20 | THZ1 | 0.497469085347 | -0.4365 | 0.0947 | 0.7408 | -1.0000 | 2.7590 | 0.9734 | 1.11022302463e-16 |
| BT-20 | THZ531 | 1.39952715577 | 0.5663 | 0.0377 | 3.3807 | -1.0000 | 1.2457 | 0.6737 | 8.31588281125e-07 |
| BT-20 | Senexin B | 2.23064370113 | 0.0956 | 0.2772 | 71.2131 | -1.0000 | 0.3172 | 0.7918 | 3.02648173189e-09 |
| BT-549 | MK 1775 | 0.285141860039 | -0.4630 | 0.4365 | 2.2824 | -1.0000 | 0.5282 | 0.9608 | 1.11022302463e-16 |
| BT-549 | AZD2014 | 0.149914841094 | 0.0235 | 0.4823 | 23.5998 | -1.0000 | 0.2172 | 0.9241 | 1.01030295241e-14 |