Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | THZ1 | 0.0730835628731 | -0.6529 | 0.3312 | 0.2397 | -1.0000 | 0.9250 | 0.9692 | 1.11022302463e-16 |
| MCF 10A | THZ531 | 0.357116458529 | -0.6687 | 0.1492 | 0.5711 | -1.0000 | 2.3402 | 0.9921 | 1.11022302463e-16 |
| MCF 10A | Senexin B | 13.2364754711 | 0.8231 | -0.0310 | 16.5655 | -1.0000 | 4.8970 | 0.5533 | 1.42287035656e-05 |
| MDA-MB-231 | MK 1775 | 0.0495006301623 | -0.3377 | 0.6074 | 0.0928 | -0.2732 | 0.6936 | 0.9722 | 1.11022302463e-16 |
| MDA-MB-231 | AZD2014 | 0.54209289151 | 0.2201 | 0.4003 | 113.8476 | -1.0000 | 0.2055 | 0.9249 | 8.881784197e-15 |
| MDA-MB-231 | AZD5363 | inf | 1.0802 | -0.0194 | 0.0000 | 1.0000 | 0.0100 | -0.2298 | 1.0 |
| MDA-MB-231 | AZD6738 | 8.82761747838 | 0.3448 | -0.0384 | 12.4996 | -0.9998 | 3.1583 | 0.8459 | 7.04556413211e-11 |
| MDA-MB-231 | BMS-265246 | 1.00882632349 | 0.1827 | 0.3374 | 50.4004 | -1.0000 | 0.2809 | 0.9396 | 5.55111512313e-16 |
| MDA-MB-231 | Ulixertinib | 1.24240329213 | 0.1557 | 0.2167 | 0.8358 | 0.1512 | 0.9087 | 0.9292 | 4.21884749358e-15 |
| MDA-MB-231 | Alvocidib | 0.135898926115 | -0.3881 | 0.2892 | 0.4189 | -0.9657 | 0.9554 | 0.9765 | 1.11022302463e-16 |
| MDA-MB-231 | GSK2334470 | 186.872396201 | 0.5782 | 0.1537 | 1000.0000 | -0.2356 | 0.2301 | 0.5852 | 1.67193823907e-05 |
| MDA-MB-231 | Ribociclib | 0.882152688922 | 0.2071 | 0.3624 | 164.4949 | -1.0000 | 0.2101 | 0.8981 | 4.00901534192e-13 |
| MDA-MB-231 | LY3023414 | 0.024794302589 | -0.1925 | 0.6229 | 9.4401 | -0.9822 | 0.1829 | 0.8678 | 1.03200781254e-11 |
| MDA-MB-231 | RO-3306 | 8.57955379445 | 0.0936 | -0.0084 | 10.6878 | -1.0000 | 5.0000 | 0.9180 | 2.64233079861e-14 |
| MDA-MB-231 | Rucaparib | 31.9983825044 | 0.5482 | 0.0971 | 279.5298 | -1.0000 | 0.5069 | 0.4838 | 0.000257239637118 |
| MDA-MB-231 | SHP099 | inf | 0.9470 | -0.0146 | 0.0000 | 1.0000 | 0.0100 | -0.0002 | 0.198394332856 |
| MDA-MB-231 | THZ1 | 0.0637722395519 | -0.4824 | 0.3383 | 0.1459 | -0.6653 | 1.0222 | 0.9846 | 1.11022302463e-16 |
| MDA-MB-231 | THZ531 | 0.237593052092 | -0.2649 | 0.2086 | 0.6335 | -1.0000 | 1.1202 | 0.9732 | 1.11022302463e-16 |
| MDA-MB-231 | Senexin B | inf | 0.8570 | 0.0825 | 0.0000 | 0.9166 | 0.0100 | 0.0000 | 0.184944177707 |