Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Rucaparib | 393.76851487 | 0.6543 | 0.1142 | 1000.0000 | -0.1347 | 0.2559 | 0.6361 | 3.25718008165e-06 |
| HCC1806 | SHP099 | inf | 0.9525 | -0.0087 | 0.0000 | 1.0000 | 0.0100 | -0.0671 | 0.950463130981 |
| HCC1806 | THZ1 | -inf | -0.5805 | ||||||
| HCC1806 | THZ531 | 0.42082047888 | -0.3750 | 0.1164 | 0.6984 | -1.0000 | 2.1690 | 0.9729 | 1.11022302463e-16 |
| HCC1806 | Senexin B | inf | 0.8083 | 0.1042 | 0.1453 | 0.7979 | 0.4002 | 0.4857 | 0.000245355132328 |
| HCC1954 | MK 1775 | 1.30961385046 | -0.4209 | 0.3053 | 5.8191 | -1.0000 | 0.7366 | 0.8046 | 1.37290245839e-09 |
| HCC1954 | AZD2014 | 0.0339995540258 | 0.0229 | 0.5840 | 1.3220 | -0.5671 | 0.2071 | 0.8957 | 5.35460564777e-13 |
| HCC1954 | AZD5363 | 2.96992805185 | 0.2599 | 0.2385 | 51.5317 | -1.0000 | 0.3850 | 0.8789 | 3.45068418284e-12 |
| HCC1954 | AZD6738 | 5.21852308366 | 0.1138 | -0.0199 | 5.0338 | 0.0824 | 5.0000 | 0.8519 | 4.27073931775e-11 |
| HCC1954 | BMS-265246 | -inf | -0.1012 | ||||||
| HCC1954 | Ulixertinib | 2.75874205583 | 0.2574 | 0.2843 | 57.3582 | -1.0000 | 0.3620 | 0.7744 | 8.25544232974e-09 |
| HCC1954 | Alvocidib | 0.122877922248 | -0.5082 | 0.3279 | 0.3492 | -1.0000 | 1.0520 | 0.9645 | 1.11022302463e-16 |
| HCC1954 | GSK2334470 | 326.758853563 | 0.7193 | 0.0862 | 1000.0000 | -0.2160 | 0.3210 | 0.3690 | 0.00316182428427 |
| HCC1954 | Ribociclib | 66.3393103634 | 0.5260 | 0.3269 | 43.1744 | 0.0265 | 0.1268 | 0.4412 | 0.000692485845485 |
| HCC1954 | LY3023414 | 0.000261242275613 | -0.4250 | 0.8272 | 1.0238 | -1.0000 | 0.1328 | 0.7220 | 1.12126955498e-07 |
| HCC1954 | RO-3306 | 6.64148500206 | -0.1134 | 0.0533 | 9.5343 | -1.0000 | 3.0385 | 0.9127 | 5.7620574978e-14 |
| HCC1954 | Rucaparib | inf | 0.8492 | 0.0892 | 0.0000 | 0.9429 | 0.0100 | 0.0000 | 1.0 |
| HCC1954 | SHP099 | 13.6734806011 | 0.6202 | 0.0988 | 60.2887 | -1.0000 | 0.7405 | 0.6988 | 3.06389488114e-07 |
| HCC1954 | THZ1 | 0.0965224052209 | -0.5246 | 0.2985 | 0.1858 | -0.6687 | 1.2967 | 0.9764 | 1.11022302463e-16 |
| HCC1954 | THZ531 | 0.359985730718 | -0.4074 | 0.1394 | 0.6797 | -1.0000 | 1.7285 | 0.9492 | 1.11022302463e-16 |
| HCC1954 | Senexin B | 211.891286993 | 0.4085 | 0.3284 | 0.0138 | 0.4972 | 0.5378 | 0.5891 | 1.48480209144e-05 |
| HCC70 | MK 1775 | 0.000494343213706 | -0.7213 | 1.1390 | 0.0113 | -0.7848 | 0.3020 | 0.9292 | 4.21884749358e-15 |
| HCC70 | AZD2014 | 0.000212092429893 | 0.0222 | 0.7748 | 0.0025 | -0.2340 | 0.1552 | 0.8423 | 9.37158128878e-11 |
| HCC70 | AZD5363 | 0.0251705169742 | -0.2793 | 0.6653 | 0.5821 | -0.6722 | 0.2713 | 0.8708 | 7.80986386673e-12 |
| HCC70 | AZD6738 | 1.73555477677 | -0.5435 | 0.2705 | 4.4527 | -1.0000 | 1.1660 | 0.9336 | 1.88737914186e-15 |