Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC70 | BMS-265246 | 0.00319357669583 | -0.1940 | 0.9108 | 0.0045 | -0.1529 | 0.7677 | 0.9705 | 1.11022302463e-16 |
| HCC70 | Ulixertinib | 1.412958526 | 0.3819 | 0.2819 | 0.0475 | 0.4787 | 0.9295 | 0.8473 | 6.27075058546e-11 |
| HCC70 | Alvocidib | 0.0750808131344 | -0.8534 | 0.4131 | 0.1347 | -0.9337 | 1.8026 | 0.9849 | 1.11022302463e-16 |
| HCC70 | GSK2334470 | 1.24076593852 | 0.1570 | 0.2931 | 2.9247 | -0.2245 | 0.4326 | 0.8858 | 1.66633373766e-12 |
| HCC70 | Ribociclib | inf | 1.0564 | -0.0040 | 0.0000 | 1.0000 | 0.0100 | -0.1699 | 1.0 |
| HCC70 | LY3023414 | 0.00246998519581 | -0.7413 | 0.7828 | 0.7825 | -1.0000 | 0.1908 | 0.6120 | 7.2607777184e-06 |
| HCC70 | RO-3306 | 4.56146799487 | -0.1657 | 0.1027 | 4.8784 | -0.1996 | 5.0000 | 0.9160 | 3.58602036954e-14 |
| HCC70 | Rucaparib | inf | 1.1144 | -0.0414 | 0.0000 | 1.0000 | 0.0100 | -0.1078 | 1.0 |
| HCC70 | SHP099 | 9764.61460436 | 0.6611 | 0.0633 | 4.4265 | 0.4969 | 0.6621 | 0.6369 | 3.16734529349e-06 |
| HCC70 | THZ1 | -inf | -0.8868 | ||||||
| HCC70 | THZ531 | 0.0645734883647 | -0.8397 | 0.4266 | 0.0849 | -0.7832 | 3.4505 | 0.9663 | 1.11022302463e-16 |
| HCC70 | Senexin B | 16.531300381 | 0.4078 | 0.2194 | 1000.0000 | -0.7732 | 0.2278 | 0.4788 | 0.000290238214042 |
| MCF 10A | MK 1775 | 6.09709750724 | 0.0219 | 0.0882 | 10.8200 | -1.0000 | 1.9153 | 0.9738 | 1.11022302463e-16 |
| MCF 10A | AZD2014 | 0.432150800137 | 0.0828 | 0.4111 | 4.6296 | -0.4698 | 0.2793 | 0.9640 | 1.11022302463e-16 |
| MCF 10A | AZD5363 | 61.7286667806 | 0.7916 | 0.0307 | 77.1806 | -0.0911 | 0.7489 | 0.9088 | 9.96980276113e-14 |
| MCF 10A | AZD6738 | 9.21613673637 | 0.4291 | 0.0314 | 16.0807 | -0.9996 | 1.9730 | 0.9840 | 1.11022302463e-16 |
| MCF 10A | BMS-265246 | 0.454251489017 | 0.0186 | 0.3954 | 6.2231 | -0.7970 | 0.3642 | 0.9860 | 1.11022302463e-16 |
| MCF 10A | Ulixertinib | 1.28240745441 | 0.1637 | 0.3045 | 35.9148 | -1.0000 | 0.3297 | 0.9680 | 1.11022302463e-16 |
| MCF 10A | Alvocidib | -inf | -0.7589 | ||||||
| MCF 10A | GSK2334470 | 15.0731115613 | 0.8830 | -0.0129 | 18.7770 | -1.0000 | 5.0000 | 0.4636 | 0.000172093714918 |
| MCF 10A | Ribociclib | 11.7857143478 | 0.4369 | 0.2382 | 1000.0000 | -0.8407 | 0.2221 | 0.8769 | 4.26025881239e-12 |
| MCF 10A | LY3023414 | 0.157364650671 | 0.0496 | 0.4399 | 0.1188 | 0.0589 | 0.4459 | 0.9485 | 1.11022302463e-16 |
| MCF 10A | RO-3306 | 5.73070119167 | -0.1356 | 0.1173 | 9.4363 | -1.0000 | 2.2028 | 0.9791 | 1.11022302463e-16 |
| MCF 10A | Rucaparib | 365.312204082 | 0.8656 | 0.0388 | 751.5036 | -0.2094 | 0.4850 | 0.5902 | 1.43637187561e-05 |
| MCF 10A | SHP099 | 12.6565255244 | 0.5479 | 0.0718 | 37.6378 | -1.0000 | 1.0081 | 0.7980 | 2.06901540345e-09 |