Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
---|---|---|---|---|---|---|---|---|
HCC1419 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9816 | -0.0058 | 0.0000 | 1.0000 | 0.0100 |
HCC1419 | HY-17542 | 72 | inf | 0.8046 | 0.0234 | 7.3179 | 0.8511 | 5.0000 |
CAMA-1 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9375 | 0.0403 | 0.0000 | 0.9497 | 0.0100 |
HCC1419 | IU1 | 72 | inf | 0.6981 | 0.0438 | 17.0535 | 0.7480 | 5.0000 |
CAMA-1 | z-VAE(OMe)-fmk | 72 | inf | 0.9619 | 0.0262 | 0.0000 | 0.9726 | 0.0100 |
CAMA-1 | HY-17542 | 72 | inf | 0.8374 | 0.0179 | 0.0000 | 0.9681 | 0.0100 |
BT-549 | Spautin-1 | 72 | inf | 0.6348 | 0.1075 | 13.3350 | 0.5009 | 0.6856 |
CAMA-1 | IU1 | 72 | inf | 0.7385 | 0.0833 | 0.9170 | 0.8015 | 5.0000 |
BT-549 | z-VAE(OMe)-fmk | 72 | inf | 0.9727 | 0.0182 | 0.0000 | 0.9828 | 0.0100 |
BT-549 | STK547622 | 72 | inf | 0.9826 | 0.0068 | 0.0000 | 0.9966 | 0.0100 |
CAMA-1 | STK547622 | 72 | inf | 0.8258 | 0.0467 | 0.0000 | 0.9496 | 0.0100 |
BT-549 | SB1-F-22 | 72 | inf | 0.8206 | 0.0279 | 14.6898 | 0.8108 | 2.3064 |
BT-20 | HY-17542 | 72 | inf | 1.0099 | -0.0181 | 0.0000 | 1.0000 | 0.0100 |
BT-20 | Doxycycline | 72 | inf | 0.5650 | 0.0355 | 0.0000 | 0.9177 | 0.0100 |
BT-20 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0460 | 0.0369 | 0.0000 | 0.9732 | 0.0100 |
BT-549 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9516 | 0.0187 | 0.0000 | 0.9793 | 0.0100 |
BT-20 | SB1-F-22 | 72 | inf | 0.8486 | -0.0325 | 0.0000 | 1.0000 | 0.0100 |
BT-20 | z-VAE(OMe)-fmk | 72 | inf | 0.9762 | 0.0198 | 0.0000 | 0.9890 | 0.0100 |
BT-20 | IU1 | 72 | inf | 1.1490 | -0.1850 | 0.0000 | 1.0000 | 0.0100 |
BT-20 | STK547622 | 72 | inf | 1.1526 | -0.0532 | 0.0000 | 1.0000 | 0.0100 |
BT-549 | IU1 | 72 | inf | 0.9301 | 0.0193 | 16.1731 | 0.9293 | 3.6587 |
BT-20 | Spautin-1 | 72 | inf | 0.5940 | 0.0846 | 8.5501 | 0.5911 | 1.1552 |
BT-20 | GW7647 | 72 | inf | 0.7093 | -0.0625 | 0.0000 | 1.0000 | 0.0100 |
HCC1419 | z-VAE(OMe)-fmk | 72 | inf | 0.9275 | 0.0463 | 0.0000 | 0.9622 | 0.0100 |
HCC1419 | STK547622 | 72 | inf | 1.0781 | 0.0128 | 0.0000 | 1.0000 | 0.0100 |