Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Dasatinib
BCR/ABL
MAPK/nRTK
0.021598
 -0.1339 0.7143 0.0924 1.3176
0.024774
0.99367
PDX1258 Trametinib
MEK
MAPK/nRTK
Inf
 0.8500 0.0424 0.0050 4.9997
0.028253
0.88698
PDX1258 Saracatinib
SRC
MAPK/nRTK
0.7252
 0.1837 0.2770 0.0370 0.8198
0.50742
0.98008
PDX1258 ABT-737
Bcl2/XL
Misc
Inf
 0.7580 0.0124 0.0237 0.9162
13.677
0.78603
PDX1258 Vorinostat
HDAC
Misc
1.5746
 -0.0232 0.2113 0.0249 1.3725
1.8225
0.99287
PDX1258 Luminespib
HSP90
Misc
0.01007
 -0.2899 0.6101 0.1943 5.0000
0.011049
0.99799
PDX1258 A-1210477
Mcl-1
Misc
Inf
 0.9187 -0.0034 0.0025 2.4151
15.1662
0.71902
PDX1258 Olaparib
PARP
Misc
11.9912
 0.5770 0.0287 0.0113 1.2287
29.2905
0.94883
PDX1258 Bleomycin
Radiation
Misc
0.78329
 0.0721 0.2946 0.0937 0.8662
0.88979
0.99416
PDX1258 Ipatasertib
AKT
PI3K/mTOR
4.4024
 0.3985 0.1556 0.0120 0.7553
1.2185
0.94717
PDX1258 Alpelisib
PI3Ka
PI3K/mTOR
17.8572
 0.6307 0.0589 0.0069 0.7348
79.6392
0.9089
PDX1258 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.99608
 0.1062 0.2777 0.0362 0.6747
1.3027
0.98871
PDX1258 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9970 -0.0328 0.0026 0.0000
Inf
-2.2747
PDX1258 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.035598
 -0.2066 0.3637 0.0836 1.5171
0.041875
0.98779
PDX1258 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.6306 0.3069 0.0224 0.5438
0.0017976
0.96445
PDX1258 INK-128
mTORC1/2
PI3K/mTOR
0.044023
 -0.1381 0.4558 0.0805 1.5509
0.046987
0.98841
PDX1258 PF-4708671
p70S6K
PI3K/mTOR
37.9842
 0.7746 0.0101 0.0075 0.8732
50.5425
0.81305
PDX1258 Buparlisib
pan PI3K
PI3K/mTOR
1.3631
 -0.3924 0.2516 0.0862 1.2064
2.8058
0.99443
PDX1258 Pictilisib
pan PI3K
PI3K/mTOR
1.6968
 0.0518 0.2298 0.0223 0.6139
6.9112
0.98576
PDX1258 Ceritinib
ALK
RTK
2.081
 -0.6841 0.2165 0.0876 1.5671
4.1949
0.9759
PDX1258 Neratinib
EGFR/HER2
RTK
1.0987
 0.2030 0.1614 0.0244 0.6264
6.3474
0.97433
PDX1258 Tivantinib
MET
RTK
0.39607
 -0.2089 0.3834 0.1084 1.2903
0.54289
0.9956
PDX1258 Cediranib
VEGFR/cKIT
RTK
4.7159
 -0.5611 0.0744 0.0681 4.9799
5.5703
0.99375
PDX1258 Cabozantinib
VEGFR2/MET
RTK
8.2309
 0.2796 0.0244 0.0160 3.8695
8.9263
0.98303
PDX1328 Abemaciclib
CDK4/6
Cell cycle
0.0036552
 -0.7514 0.8680 0.0940 0.2489
0.30192
0.79917