Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1806 Abemaciclib
CDK4/6
Cell cycle
0.59453
-0.4440 0.3921 0.1035 0.6190
3.5069
0.96621
HCC1806 Palbociclib
CDK4/6
Cell cycle
Inf
0.6924 0.1460 0.0085 1.6543
0.024125
0.93749
HCC1806 AZD7762
CHK1/2
Cell cycle
0.016629
-0.4822 0.8897 0.3907 1.6771
0.023183
0.99277
HCC1806 Volasertib
PLK
Cell cycle
0.0027998
-0.1323 0.7262 0.2950 5.0000
0.0029495
0.99776
HCC1806 Dinaciclib
pan CDK
Cell cycle
0.013395
-0.4585 0.6439 0.3114 3.4710
0.016174
0.99891
HCC1806 Cisplatin
Chemo
Chemotherapy
0.82764
-0.3648 0.3231 0.1009 1.1777
1.5296
0.98889
HCC1806 Doxorubicin
Chemo
Chemotherapy
0.015898
-0.3241 0.6281 0.1971 1.0948
0.021206
0.97525
HCC1806 Taxol
Chemo
Chemotherapy
0.0014225
-0.2113 0.8398 0.3493 2.1569
0.0016621
0.96243
HCC1806 Topotecan
Topo I
Chemotherapy
0.0052709
-0.5458 1.0747 0.3515 1.0834
0.0094879
0.95633
HCC1806 Etoposide
Topo II
Chemotherapy
0.096233
-0.5629 0.6490 0.2019 0.9767
0.2057
0.99535
HCC1806 Dasatinib
BCR/ABL
MAPK/nRTK
0.053677
-0.0992 0.6297 0.1625 1.4311
0.062326
0.98998
HCC1806 Trametinib
MEK
MAPK/nRTK
Inf
0.7036 0.1086 0.0280 4.8006
0.007609
0.89189
HCC1806 Saracatinib
SRC
MAPK/nRTK
1.73
0.2213 0.2336 0.0480 0.6559
1.8399
0.97728
HCC1806 ABT-737
Bcl2/XL
Misc
12.0843
0.7293 -0.0285 0.0138 5.0000
12.4641
0.7932
HCC1806 Vorinostat
HDAC
Misc
1.1276
0.0178 0.2397 0.0491 1.3263
1.2167
0.99564
HCC1806 Luminespib
HSP90
Misc
0.010903
-0.1751 0.5413 0.2054 2.8582
0.012009
0.99662
HCC1806 A-1210477
Mcl-1
Misc
Inf
0.9047 -0.0078 0.0015 4.2962
12.7646
0.58471
HCC1806 Olaparib
PARP
Misc
10.3367
0.4886 0.0953 0.0224 0.7744
42.7088
0.92848
HCC1806 Bleomycin
Radiation
Misc
8.9432
0.4813 0.1206 0.0253 0.8891
1.9034
0.96208
HCC1806 Ipatasertib
AKT
PI3K/mTOR
Inf
0.9450 0.0145 -0.0020 0.0000
Inf
0.32254
HCC1806 Alpelisib
PI3Ka
PI3K/mTOR
24.5643
0.7260 0.0386 0.0042 0.9323
42.9713
0.94371
HCC1806 Taselisib
PI3Ka, g, d
PI3K/mTOR
1.5787
-0.0297 0.2583 0.0605 0.5749
10.6705
0.98019
HCC1806 TGX221
PI3Kb
PI3K/mTOR
Inf
0.9819 -0.0154 0.0035 0.0000
Inf
-0.19348
HCC1806 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.03581
-0.1402 0.3877 0.1005 0.9893
0.048229
0.99141
HCC1806 Everolimus
mTOR1
PI3K/mTOR
Inf
0.8168 0.1972 0.0004 0.0000
Inf
-2.9998e-08
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