Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | Saracatinib | SRC | MAPK/nRTK | Inf | 1.0500 | -0.0500 | 0.0181 | 0.0000 | Inf | -Inf |
| PDXHCI002 | Ipatasertib | AKT | PI3K/mTOR | Inf | 1.0500 | -0.0488 | -0.0112 | 0.0000 | Inf | -59.6281 |
| PDX1258 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0159 | -0.0479 | 0.0014 | 0.0000 | Inf | -18.593 |
| PDXHCI002 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.9869 | -0.0453 | -0.0479 | 0.0000 | Inf | -4.5815 |
| CAL-85-1 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0418 | -0.0009 | 0.0000 | Inf | -4.681 |
| BT-20 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0152 | -0.0415 | -0.0034 | 0.0000 | Inf | -7.4504 |
| HCC1937 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0406 | -0.0017 | 0.0000 | Inf | -4.6521 |
| BT-549 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0401 | -0.0011 | 0.0000 | Inf | -9.2879 |
| HCC1428 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9911 | -0.0383 | -0.0001 | 0.0000 | Inf | -2.9826 |
| MDA-MB-134-VI | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8589 | -0.0381 | -0.0029 | 0.0000 | Inf | 0.38211 |
| PDXHCI002 | A-1210477 | Mcl-1 | Misc | Inf | 0.9814 | -0.0380 | 0.0049 | 0.0000 | Inf | -2.2577 |
| HCC1954 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9607 | -0.0374 | -0.0050 | 0.0000 | Inf | -1.0282 |
| HCC1500 | A-1210477 | Mcl-1 | Misc | Inf | 0.8719 | -0.0368 | 0.0081 | 0.0000 | Inf | 0.32761 |
| MDA-MB-134-VI | A-1210477 | Mcl-1 | Misc | Inf | 1.0500 | -0.0366 | -0.0033 | 0.0000 | Inf | -3.0589 |
| MDA-MB-453 | A-1210477 | Mcl-1 | Misc | Inf | 0.9330 | -0.0364 | 0.0157 | 0.0000 | Inf | -0.33803 |
| MDA-MB-436 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0343 | -0.0002 | 0.0000 | Inf | -9.0203 |
| MDA-MB-361 | TGX221 | PI3Kb | PI3K/mTOR | 13.225 | 0.7989 | -0.0336 | 0.0006 | 4.9995 | 13.1104 | 0.64936 |
| PDX1258 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9970 | -0.0328 | 0.0026 | 0.0000 | Inf | -2.2747 |
| HME1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0265 | -0.0318 | -0.0005 | 0.0000 | Inf | -0.12868 |
| HCC1500 | Ipatasertib | AKT | PI3K/mTOR | Inf | 1.0500 | -0.0314 | -0.0045 | 0.0000 | Inf | -1.0541 |
| CAL-85-1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9895 | -0.0309 | 0.0002 | 0.0000 | Inf | -1.0218 |
| MDA-MB-134-VI | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.8878 | -0.0289 | 0.0187 | 0.0000 | Inf | 0.37857 |
| MDA-MB-134-VI | PF-4708671 | p70S6K | PI3K/mTOR | 11.8417 | 0.7092 | -0.0287 | -0.0026 | 5.0000 | 12.2595 | 0.80506 |
| HCC1806 | ABT-737 | Bcl2/XL | Misc | 12.0843 | 0.7293 | -0.0285 | 0.0138 | 5.0000 | 12.4641 | 0.7932 |
| CAL-85-1 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9343 | -0.0283 | 0.0138 | 0.0000 | Inf | -0.025903 |