Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | A-1210477 | Mcl-1 | Misc | Inf | 0.9299 | 0.0206 | 0.0057 | 0.3898 | 963.6809 | 0.60314 |
| HCC1937 | A-1210477 | Mcl-1 | Misc | Inf | 0.7240 | 0.0060 | 0.0046 | 4.0529 | 5.9209 | 0.95858 |
| PDX1328 | A-1210477 | Mcl-1 | Misc | 29.0724 | 0.7094 | 0.0609 | 0.0135 | 0.6451 | 128.4233 | 0.82503 |
| MDA-MB-453 | A-1210477 | Mcl-1 | Misc | Inf | 0.9330 | -0.0364 | 0.0157 | 0.0000 | Inf | -0.33803 |
| HCC1395 | A-1210477 | Mcl-1 | Misc | 14.7951 | 0.8591 | 0.0009 | 0.0010 | 5.0000 | 13.8656 | 0.73508 |
| HCC1500 | A-1210477 | Mcl-1 | Misc | Inf | 0.8719 | -0.0368 | 0.0081 | 0.0000 | Inf | 0.32761 |
| BT-20 | A-1210477 | Mcl-1 | Misc | 14.9935 | 0.8209 | -0.0262 | 0.0007 | 4.9994 | 12.3309 | 0.67398 |
| SK-BR-3 | A-1210477 | Mcl-1 | Misc | 11.3859 | 0.6275 | 0.0389 | 0.0040 | 4.3303 | 10.9082 | 0.92796 |
| MDA-MB-134-VI | A-1210477 | Mcl-1 | Misc | Inf | 1.0500 | -0.0366 | -0.0033 | 0.0000 | Inf | -3.0589 |
| MDA-MB-436 | A-1210477 | Mcl-1 | Misc | Inf | 0.8728 | 0.0140 | 0.0010 | 0.0000 | Inf | 0.42977 |
| CAL-51 | A-1210477 | Mcl-1 | Misc | Inf | 0.9919 | 0.0073 | 0.0004 | 0.0000 | Inf | 0.00046652 |
| HCC70 | A-1210477 | Mcl-1 | Misc | Inf | 0.9380 | 0.0054 | 0.0123 | 0.0000 | Inf | 0.17964 |
| PDX1258 | A-1210477 | Mcl-1 | Misc | Inf | 0.9187 | -0.0034 | 0.0025 | 2.4151 | 15.1662 | 0.71902 |
| HCC1419 | A-1210477 | Mcl-1 | Misc | 14.536 | 0.7081 | 0.0402 | 0.0018 | 1.8053 | 26.3399 | 0.8672 |
| MCF7 | A-1210477 | Mcl-1 | Misc | Inf | 0.8774 | -0.0002 | 0.0007 | 1.8795 | 11.2338 | 0.74456 |
| HCC1806 | A-1210477 | Mcl-1 | Misc | Inf | 0.9047 | -0.0078 | 0.0015 | 4.2962 | 12.7646 | 0.58471 |
| MDA-MB-231 | A-1210477 | Mcl-1 | Misc | Inf | 0.9569 | 0.0519 | 0.0034 | 0.0000 | Inf | -8.5977e-09 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| BT-549 | A-1210477 | Mcl-1 | Misc | Inf | 0.9540 | 0.0083 | 0.0018 | 0.0000 | Inf | 0.34182 |
| HCC38 | A-1210477 | Mcl-1 | Misc | 14.9391 | 0.8870 | 0.0151 | 0.0032 | 4.9989 | 15.3353 | 0.65537 |
| MDA-MB-157 | A-1210477 | Mcl-1 | Misc | 13.1155 | 0.7884 | 0.0063 | 0.0017 | 4.9648 | 12.9049 | 0.88212 |
| MDA-MB-361 | A-1210477 | Mcl-1 | Misc | Inf | 0.9850 | -0.0083 | 0.0037 | 0.0000 | Inf | -0.045307 |
| Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
| CAL-120 | A-1210477 | Mcl-1 | Misc | Inf | 0.9427 | 0.0152 | 0.0003 | 0.0000 | Inf | 0.34764 |
| HCC1954 | A-1210477 | Mcl-1 | Misc | Inf | 0.8844 | -0.0259 | 0.0076 | 0.0000 | Inf | 0.43063 |