Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | Taxol | Chemo | Chemotherapy | 0.00012515 | -0.7183 | 1.3004 | 0.3511 | 0.5352 | 0.00075273 | 0.89205 |
| MDA-MB-134-VI | Everolimus | mTOR1 | PI3K/mTOR | 0.00017047 | -0.2444 | 1.1669 | 0.1034 | 0.5948 | 0.00034979 | 0.96485 |
| MDA-MB-361 | Everolimus | mTOR1 | PI3K/mTOR | 0.00027478 | 0.0574 | 0.8497 | 0.0502 | 0.7979 | 0.00019313 | 0.7172 |
| HCC1500 | INK-128 | mTORC1/2 | PI3K/mTOR | 0.00078427 | -0.4693 | 1.2309 | 0.2717 | 1.2780 | 0.0013303 | 0.99127 |
| Hs 578T | Taxol | Chemo | Chemotherapy | 0.0010154 | -0.3752 | 0.9535 | 0.4788 | 1.2811 | 0.0015458 | 0.95438 |
| HCC1419 | Neratinib | EGFR/HER2 | RTK | 0.0011485 | -0.5015 | 0.9927 | 0.1818 | 0.5367 | 0.0038194 | 0.97246 |
| HCC70 | Taxol | Chemo | Chemotherapy | 0.0013411 | -0.5065 | 0.9773 | 0.3742 | 1.1642 | 0.0024269 | 0.99734 |
| MDA-MB-468 | Taxol | Chemo | Chemotherapy | 0.001354 | -0.5218 | 1.0076 | 0.5243 | 1.2795 | 0.0023644 | 0.95471 |
| MCF7 | Taxol | Chemo | Chemotherapy | 0.0013771 | -0.1059 | 0.7722 | 0.1589 | 1.1560 | 0.0016261 | 0.94939 |
| HCC1806 | Taxol | Chemo | Chemotherapy | 0.0014225 | -0.2113 | 0.8398 | 0.3493 | 2.1569 | 0.0016621 | 0.96243 |
| HCC38 | Taxol | Chemo | Chemotherapy | 0.0014659 | -0.3078 | 0.8432 | 0.2758 | 2.3201 | 0.0017274 | 0.99328 |
| CAL-85-1 | Everolimus | mTOR1 | PI3K/mTOR | 0.0015471 | 0.3707 | 0.5762 | 0.0915 | 5.0000 | 0.0011149 | 0.86907 |
| SUM149PT | Taxol | Chemo | Chemotherapy | 0.0015927 | -0.2583 | 0.8405 | 0.3816 | 3.1045 | 0.0017914 | 0.99574 |
| SK-BR-3 | Neratinib | EGFR/HER2 | RTK | 0.0016518 | -0.2530 | 0.8909 | 0.2029 | 0.7723 | 0.0025421 | 0.9721 |
| HCC1500 | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.0017504 | -0.4967 | 0.9053 | 0.2022 | 1.3577 | 0.0027734 | 0.99119 |
| MDA-MB-361 | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0017737 | -0.9902 | 1.4103 | 0.4329 | 0.6207 | 0.010237 | 0.9975 |
| T47D | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0017858 | -0.1047 | 0.8990 | 0.0550 | 1.1740 | 0.0018197 | 0.97255 |
| CAL-120 | Volasertib | PLK | Cell cycle | 0.0018536 | 0.0258 | 0.6758 | 0.2649 | 2.5191 | 0.001844 | 0.99276 |
| T47D | Doxorubicin | Chemo | Chemotherapy | 0.0018887 | -0.3611 | 0.9189 | 0.1014 | 1.2268 | 0.0024801 | 0.96538 |
| HCC70 | Trametinib | MEK | MAPK/nRTK | 0.0019047 | -0.0393 | 0.6924 | 0.1954 | 0.8693 | 0.0021049 | 0.98467 |
| SK-BR-3 | Taxol | Chemo | Chemotherapy | 0.0019068 | -0.3401 | 0.8905 | 0.3665 | 2.3888 | 0.0023578 | 0.96349 |
| BT-20 | Taxol | Chemo | Chemotherapy | 0.0020158 | -0.5760 | 0.9854 | 0.4456 | 2.0677 | 0.0028795 | 0.99355 |
| MDA-MB-157 | Taxol | Chemo | Chemotherapy | 0.002046 | -0.6700 | 0.9482 | 0.3487 | 1.9966 | 0.0029397 | 0.97064 |
| MDA-MB-134-VI | Trametinib | MEK | MAPK/nRTK | 0.0020578 | -0.2707 | 0.7601 | 0.0782 | 1.0824 | 0.0028809 | 0.99008 |
| HCC1143 | Taxol | Chemo | Chemotherapy | 0.0020688 | -0.3349 | 0.8388 | 0.3074 | 2.5955 | 0.0024565 | 0.99279 |