Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | Everolimus | mTOR1 | PI3K/mTOR | -Inf | 0.1642 | 0.7666 | 0.0258 | 0.1000 | 1.9385e-07 | 0.61758 |
| T47D | Everolimus | mTOR1 | PI3K/mTOR | -Inf | 0.2975 | 0.6157 | 0.0150 | 0.1000 | 5.9599e-07 | 0.77906 |
| SK-BR-3 | Everolimus | mTOR1 | PI3K/mTOR | -Inf | 0.1182 | 0.7944 | 0.1209 | 0.1000 | 6.3064e-07 | 0.84606 |
| MDA-MB-231 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.8544 | 0.0105 | 0.0068 | 4.2838 | 3.8501 | 0.8794 |
| MDA-MB-231 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7110 | 0.2246 | -0.0006 | 0.0000 | Inf | 0.54965 |
| MCF 10A | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.6472 | 0.0600 | -0.0019 | 1.0758 | 4.7959 | 0.99868 |
| MCF 10A | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9505 | 0.0050 | 0.0003 | 0.8181 | 270.4333 | 0.86411 |
| MDA-MB-231 | A-1210477 | Mcl-1 | Misc | Inf | 0.9569 | 0.0519 | 0.0034 | 0.0000 | Inf | -8.5977e-09 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| MCF 10A | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.7207 | 0.0475 | -0.0020 | 1.0315 | 4.381 | 0.99443 |
| MCF7 | A-1210477 | Mcl-1 | Misc | Inf | 0.8774 | -0.0002 | 0.0007 | 1.8795 | 11.2338 | 0.74456 |
| Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
| HCC1806 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.8168 | 0.1972 | 0.0004 | 0.0000 | Inf | -2.9998e-08 |
| Hs 578T | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9143 | 0.0252 | 0.0005 | 2.0096 | 0.1778 | 0.76824 |
| HCC1806 | A-1210477 | Mcl-1 | Misc | Inf | 0.9047 | -0.0078 | 0.0015 | 4.2962 | 12.7646 | 0.58471 |
| HCC1806 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.6924 | 0.1460 | 0.0085 | 1.6543 | 0.024125 | 0.93749 |
| HCC1806 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 1.0500 | -0.0207 | -0.0033 | 0.0000 | Inf | -0.67606 |
| Hs 578T | ABT-737 | Bcl2/XL | Misc | Inf | 0.7755 | 0.0260 | 0.0177 | 1.3421 | 4.2689 | 0.94189 |
| HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
| MCF 10A | ABT-737 | Bcl2/XL | Misc | Inf | 0.8170 | 0.0104 | 0.0055 | 4.1268 | 4.3547 | 0.98669 |
| MCF 10A | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7889 | 0.1130 | 0.0000 | 0.4668 | 0.070049 | 0.96385 |
| HCC1806 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9819 | -0.0154 | 0.0035 | 0.0000 | Inf | -0.19348 |
| HCC1806 | Trametinib | MEK | MAPK/nRTK | Inf | 0.7036 | 0.1086 | 0.0280 | 4.8006 | 0.007609 | 0.89189 |
| MCF7 | Trametinib | MEK | MAPK/nRTK | Inf | 0.5581 | 0.2767 | 0.0114 | 1.2083 | 0.0027903 | 0.99413 |
| MDA-MB-231 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9254 | 0.0073 | -0.0008 | 0.0000 | Inf | 0.28623 |