Taselisib - Small Molecule (ID:10445-101)
| HMS LINCS ID: |
10445-101
|
| Name: | Taselisib |
| Alternative Names: | GDC-0032; RG-7604 |
| LINCS ID: | LSM-45140 |
| PubChem CID: | 51001932 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 460.23 |
| InChi: | InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33) |
| InChi Key: | BEUQXVWXFDOSAQ-UHFFFAOYSA-N |
| SMILES: | CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
PIK3CA, PIK3CB, PIK3CD, PIK3CG | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | PIK3C2B, PIK3C3 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | MTOR, PRKDC |
10 (confirmed non-binding) |
Batch Information for HMSL10445-101-1:
| HMS LINCS Batch ID: | 10445-101-1 |
| Provider: | MedChem Express |
| Provider Batch ID: | 10661 |
| Salt: | 101 |
| Molecular Formula: | C24H28N8O2 |
| Molecular Weight: | 460.53 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-08-27 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10445-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10445-101-1_LCMS.pdf |
(Kd <100 nM)