Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
BT-549 Saracatinib
SRC
MAPK/nRTK
Inf
 0.5558 0.0348 0.0015 3.3790
3.6758
0.97565
BT-549 ABT-737
Bcl2/XL
Misc
Inf
 0.9359 -0.0225 0.0062 0.0000
Inf
0.067883
BT-549 Vorinostat
HDAC
Misc
2.3739
 0.1131 0.1887 0.0291 0.8756
3.9571
0.99525
BT-549 Luminespib
HSP90
Misc
0.0053858
 -0.1064 0.6123 0.1201 5.0000
0.0055748
0.99911
BT-549 A-1210477
Mcl-1
Misc
Inf
 0.9540 0.0083 0.0018 0.0000
Inf
0.34182
BT-549 Olaparib
PARP
Misc
11.948
 0.5432 0.0657 0.0130 0.9548
37.7564
0.91931
BT-549 Bleomycin
Radiation
Misc
0.17998
 -0.0141 0.4667 0.1506 1.0031
0.20287
0.99525
BT-549 Ipatasertib
AKT
PI3K/mTOR
12.6362
 0.4956 0.1735 0.0097 0.5079
1.6786
0.97652
BT-549 Alpelisib
PI3Ka
PI3K/mTOR
17.5141
 0.6841 0.0322 0.0099 1.0429
49.8384
0.95639
BT-549 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.2065
 0.0950 0.2229 0.0263 0.5717
15.0749
0.99278
BT-549 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.8097 0.0568 0.0017 0.6702
0.72927
0.89208
BT-549 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0095129
 -0.0209 0.4905 0.0692 1.0018
0.0092175
0.99224
BT-549 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.5197 0.4386 0.0304 0.0000
Inf
0.48985
BT-549 INK-128
mTORC1/2
PI3K/mTOR
0.016573
 0.0717 0.5339 0.0484 1.5295
0.014683
0.99934
BT-549 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.7437 -0.0070 0.0034 2.5979
8.243
0.85998
BT-549 Buparlisib
pan PI3K
PI3K/mTOR
1.419
 -0.2716 0.2487 0.0802 2.0178
1.8107
0.99484
BT-549 Pictilisib
pan PI3K
PI3K/mTOR
2.7775
 0.1463 0.2083 0.0210 0.6027
17.1916
0.98946
BT-549 Ceritinib
ALK
RTK
2.961
 -0.2284 0.1416 0.0526 1.8781
4.216
0.99556
BT-549 Neratinib
EGFR/HER2
RTK
1.9856
 0.2081 0.0800 0.0141 1.4334
4.2733
0.98836
BT-549 Tivantinib
MET
RTK
0.58217
 -0.2649 0.3472 0.1072 2.4717
0.68658
0.99761
BT-549 Cediranib
VEGFR/cKIT
RTK
3.6412
 -0.1347 0.1497 0.0414 1.3011
8.4712
0.98092
BT-549 Cabozantinib
VEGFR2/MET
RTK
10.1855
 0.5329 0.0124 0.0096 5.0000
12.5665
0.95054
HCC38 Abemaciclib
CDK4/6
Cell cycle
0.044561
 -0.3272 0.6404 0.0910 0.4303
0.21535
0.96385
HCC38 Palbociclib
CDK4/6
Cell cycle
0.059804
 0.1474 0.3722 0.0411 1.0985
0.037879
0.98636
HCC38 AZD7762
CHK1/2
Cell cycle
0.0094764
 -0.3341 0.9185 0.2951 2.0434
0.01177
0.98869