Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
BT-20 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.018077
 -0.3749 0.7363 0.2005 0.7541
0.028401
0.95352
BT-20 TGX221
PI3Kb
PI3K/mTOR
Inf
 1.0152 -0.0415 -0.0034 0.0000
Inf
-7.4504
BT-20 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.008897
 -0.2891 0.5365 0.1367 0.8675
0.012533
0.97198
BT-20 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.3900 0.5932 0.0889 0.0000
Inf
0.031152
BT-20 INK-128
mTORC1/2
PI3K/mTOR
0.012881
 -0.0045 0.5675 0.1137 1.3697
0.01193
0.99574
BT-20 PF-4708671
p70S6K
PI3K/mTOR
15.1446
 0.6601 0.0129 0.0102 1.1942
37.9666
0.89476
BT-20 Buparlisib
pan PI3K
PI3K/mTOR
0.63756
 -0.5514 0.3662 0.1474 1.2077
1.2887
0.99431
BT-20 Pictilisib
pan PI3K
PI3K/mTOR
0.90394
 -0.1650 0.2960 0.0736 0.9819
1.5458
0.99177
BT-20 Ceritinib
ALK
RTK
1.5315
 -0.7365 0.2591 0.1255 1.7439
2.7905
0.99717
BT-20 Neratinib
EGFR/HER2
RTK
1.2826
 0.3026 0.1496 0.0391 0.6768
2.19
0.97744
BT-20 Tivantinib
MET
RTK
0.47342
 -0.4883 0.4183 0.1893 2.5782
0.60346
0.99447
BT-20 Cediranib
VEGFR/cKIT
RTK
5.6982
 0.2210 0.0383 0.0150 2.7852
5.3221
0.97585
BT-20 Cabozantinib
VEGFR2/MET
RTK
5.3516
 -0.2030 0.0566 0.0432 4.9846
5.8613
0.99079
BT-549 Abemaciclib
CDK4/6
Cell cycle
3.9707
 0.0333 0.1267 0.0188 1.2825
7.5655
0.99654
BT-549 Palbociclib
CDK4/6
Cell cycle
Inf
 1.0500 -0.0401 -0.0011 0.0000
Inf
-9.2879
BT-549 AZD7762
CHK1/2
Cell cycle
0.066029
 -0.4824 0.6356 0.2312 1.6999
0.087287
0.97383
BT-549 Volasertib
PLK
Cell cycle
0.0088352
 -0.2289 0.5676 0.1490 2.4967
0.0098732
0.99586
BT-549 Dinaciclib
pan CDK
Cell cycle
0.012371
 -0.2923 0.5913 0.1485 3.7837
0.013904
0.99899
BT-549 Cisplatin
Chemo
Chemotherapy
1.016
 0.0674 0.2835 0.0552 1.0827
1.0937
0.98489
BT-549 Doxorubicin
Chemo
Chemotherapy
0.006482
 -0.3312 0.7603 0.1972 1.5744
0.0079126
0.9824
BT-549 Taxol
Chemo
Chemotherapy
0.0027257
 -0.2074 0.6989 0.2304 1.9420
0.0030953
0.98743
BT-549 Topotecan
Topo I
Chemotherapy
0.0084727
 -0.2410 0.8509 0.2269 1.4734
0.010061
0.9801
BT-549 Etoposide
Topo II
Chemotherapy
0.181
 -0.1948 0.4726 0.1408 1.1701
0.22766
0.99526
BT-549 Dasatinib
BCR/ABL
MAPK/nRTK
0.59323
 0.3705 0.2386 0.0271 1.7859
0.13859
0.96413
BT-549 Trametinib
MEK
MAPK/nRTK
5.2409
 0.5983 0.1292 0.0152 0.5005
0.36186
0.97942