Cediranib - Small Molecule (ID:10444-101)

HMS LINCS ID: 10444-101
Name: Cediranib
Alternative Names: Recentin; AZD2171
LINCS ID:
PubChem CID: 9933475
ChEBI ID:
ChEMBL ID:
Molecular Mass: 450.21
InChi: InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
InChi Key: XXJWYDDUDKYVKI-UHFFFAOYSA-N
SMILES: CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, CSF1R, DDR1, DDR2, EPHA6, FGFR1, FGFR2, FGFR3, FLG, FLT1, FLT4, KDR, KIT, MAP4K5, PDGFRA, PDGFRB, RET, RIPK2, SLK, SRC, STK10, STK35, TKT
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL2, AXL, BLK, EGFR, EPHA7, EPHB6, ERBB3, ERN1, FGFR4, FRK, FYN, HCK, LCK, LYN, MAP3K19, MAP4K1, MET, PTK6, STK33, TEK, TIE1, TNIK, TYRO3, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ACVR1, ACVR1B, AIM1, AKT1, AKT2, ALK, AURKA, AURKB, AURKC, BTK, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC7, CDK1, CDK2, CDK5, CDK7, CDK8, CDK9, CHEK1, CHEK2, CHUK, CLK2, CLK4, CSNK1A1, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK1B, DYRK3, DYRK4, EEF2K, EIF2AK1, EPHA1, EPHA2, EPHA3, EPHA8, EPHB4, ERBB2, ERBB4, FER, FES, FGR, GAK, GRK5, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, IKBKE, INSR, IRAK1, ITK, JAK2, JAK3, LIMK1, LTK, MAP2K1, MAP2K2, MAP2K5, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MERTK, MINK1, MST1, MST1R, NEK2, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PDK1, PDPK1, PHKG2, PIM1, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCQ, PRKCZ, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, ROCK1, ROCK2, ROS1, RPS6KA3, RPS6KB1, SIK2, SRMS, SRPK1, STK17A, STK26, STK4, SYK, TAOK1, TAOK2, TAOK3, TBK1, TGFBR1, TNK2, TSSK1B, TSSK2
10
(confirmed non-binding)
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Batch Information for HMSL10444-101-1:

HMS LINCS Batch ID: 10444-101-1
Provider: MedChem Express
Provider Batch ID: 10890
Salt: 101
Molecular Formula: C25H27FN4O3
Molecular Weight: 450.51
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-08-27
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10444-101-1:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10444-101-1_LCMS.pdf