Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Neratinib
EGFR/HER2
RTK
0.0016518
 -0.2530 0.8909 0.2029 0.7723
0.0025421
0.9721
SK-BR-3 Tivantinib
MET
RTK
0.27263
 -0.3523 0.4830 0.2060 2.4177
0.34098
0.99571
SK-BR-3 Cediranib
VEGFR/cKIT
RTK
6.1955
 -0.5397 0.0755 0.0528 4.8242
7.7773
0.99548
SK-BR-3 Cabozantinib
VEGFR2/MET
RTK
9.7073
 0.4422 0.0013 0.0011 5.0000
12.0523
0.95604
BT-20 Abemaciclib
CDK4/6
Cell cycle
0.061268
 -0.2160 0.5694 0.0435 0.4177
0.17789
0.93347
BT-20 Palbociclib
CDK4/6
Cell cycle
0.043794
 0.1624 0.3972 0.0216 1.2275
0.030066
0.99055
BT-20 AZD7762
CHK1/2
Cell cycle
1.081
 -0.5785 0.2831 0.1722 1.5948
1.8464
0.99406
BT-20 Volasertib
PLK
Cell cycle
0.0056337
 -0.5339 0.7904 0.3461 2.3226
0.0076094
0.99851
BT-20 Dinaciclib
pan CDK
Cell cycle
0.018482
 -0.6979 0.6791 0.3193 3.4864
0.02362
0.99822
BT-20 Cisplatin
Chemo
Chemotherapy
0.79098
 -0.3367 0.3338 0.0794 0.9579
1.7289
0.98666
BT-20 Doxorubicin
Chemo
Chemotherapy
0.0087386
 -0.4813 0.8279 0.3024 1.4443
0.013048
0.9861
BT-20 Taxol
Chemo
Chemotherapy
0.0020158
 -0.5760 0.9854 0.4456 2.0677
0.0028795
0.99355
BT-20 Topotecan
Topo I
Chemotherapy
0.012333
 -0.6410 1.0284 0.3794 0.9448
0.029071
0.99592
BT-20 Etoposide
Topo II
Chemotherapy
0.30148
 -0.3834 0.4591 0.1362 1.2176
0.48057
0.99643
BT-20 Dasatinib
BCR/ABL
MAPK/nRTK
0.67985
 0.2835 0.3289 0.0839 0.5423
0.27245
0.98321
BT-20 Trametinib
MEK
MAPK/nRTK
2.3446
 0.5034 0.1768 0.0535 0.6346
0.053945
0.96232
BT-20 Saracatinib
SRC
MAPK/nRTK
4.8514
 0.3103 0.1591 0.0406 0.5845
31.7814
0.9851
BT-20 ABT-737
Bcl2/XL
Misc
12.6171
 0.5926 0.0250 0.0397 1.1740
32.0424
0.93473
BT-20 Vorinostat
HDAC
Misc
2.217
 -0.1134 0.1610 0.0705 1.6271
2.8626
0.99345
BT-20 Luminespib
HSP90
Misc
0.005967
 -0.0490 0.5621 0.1453 4.4759
0.0060667
0.99656
BT-20 A-1210477
Mcl-1
Misc
14.9935
 0.8209 -0.0262 0.0007 4.9994
12.3309
0.67398
BT-20 Olaparib
PARP
Misc
15.2735
 0.6064 0.0657 0.0087 0.8235
57.982
0.94742
BT-20 Bleomycin
Radiation
Misc
0.4878
 -0.1286 0.3764 0.0970 0.9564
0.75174
0.99474
BT-20 Ipatasertib
AKT
PI3K/mTOR
0.64483
 0.1015 0.3111 0.0476 0.7459
0.59909
0.98219
BT-20 Alpelisib
PI3Ka
PI3K/mTOR
2.0326
 -0.1181 0.2014 0.0639 0.8192
7.7705
0.99071