Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-361 Everolimus
mTOR1
PI3K/mTOR
0.00027478
 0.0574 0.8497 0.0502 0.7979
0.00019313
0.7172
MDA-MB-361 INK-128
mTORC1/2
PI3K/mTOR
0.0036192
 -0.8457 1.0956 0.2779 1.1991
0.0074773
0.98876
MDA-MB-361 PF-4708671
p70S6K
PI3K/mTOR
7.2299
 0.1918 0.0684 0.0066 2.1808
11.9649
0.98055
MDA-MB-361 Buparlisib
pan PI3K
PI3K/mTOR
0.21797
 -0.9584 0.6114 0.1763 0.9709
0.67584
0.99384
MDA-MB-361 Pictilisib
pan PI3K
PI3K/mTOR
0.079201
 -0.9375 0.7161 0.1619 0.6291
0.45409
0.98391
MDA-MB-361 Ceritinib
ALK
RTK
0.26636
 -0.9910 0.5462 0.1443 0.8263
1.0067
0.97236
MDA-MB-361 Neratinib
EGFR/HER2
RTK
0.15196
 -0.5277 0.4246 0.0772 0.5626
1.0709
0.91404
MDA-MB-361 Tivantinib
MET
RTK
0.34234
 -0.6060 0.5161 0.1344 1.7286
0.54407
0.99764
MDA-MB-361 Cediranib
VEGFR/cKIT
RTK
2.2171
 -0.9803 0.2895 0.1040 2.2939
3.5791
0.96048
MDA-MB-361 Cabozantinib
VEGFR2/MET
RTK
Inf
 0.6624 0.0628 -0.0003 4.9832
4.0443
0.74358
MDA-MB-436 Abemaciclib
CDK4/6
Cell cycle
2.1015
 -0.3331 0.1897 0.0464 1.1593
5.3251
0.99054
MDA-MB-436 Palbociclib
CDK4/6
Cell cycle
Inf
 1.0500 -0.0343 -0.0002 0.0000
Inf
-9.0203
MDA-MB-436 AZD7762
CHK1/2
Cell cycle
0.039886
 -0.2809 0.6566 0.0949 1.4724
0.049236
0.98291
MDA-MB-436 Volasertib
PLK
Cell cycle
0.0051788
 -0.1792 0.6616 0.1034 3.6059
0.0056092
0.99947
MDA-MB-436 Dinaciclib
pan CDK
Cell cycle
0.014324
 -0.1440 0.4903 0.0235 4.8527
0.014993
0.99777
MDA-MB-436 Cisplatin
Chemo
Chemotherapy
0.4173
 -0.0204 0.3606 0.0365 1.2366
0.44452
0.99287
MDA-MB-436 Doxorubicin
Chemo
Chemotherapy
0.0076138
 -0.1288 0.7061 0.0611 1.3442
0.0088093
0.99253
MDA-MB-436 Taxol
Chemo
Chemotherapy
0.0037097
 -0.2183 0.7083 0.1530 3.2043
0.0040962
0.99739
MDA-MB-436 Topotecan
Topo I
Chemotherapy
0.0059389
 -0.1398 0.8768 0.0855 1.0160
0.0074925
0.99666
MDA-MB-436 Etoposide
Topo II
Chemotherapy
0.26013
 -0.1571 0.4348 0.0454 0.9014
0.38084
0.99169
MDA-MB-436 Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.6528 0.1022 0.0098 0.0000
Inf
0.40773
MDA-MB-436 Trametinib
MEK
MAPK/nRTK
Inf
 0.5572 0.1820 0.0015 1.0351
0.021252
0.93697
MDA-MB-436 Saracatinib
SRC
MAPK/nRTK
37.3252
 0.7236 0.0385 0.0048 0.7263
42.6009
0.88237
MDA-MB-436 ABT-737
Bcl2/XL
Misc
26.1321
 0.8154 0.0064 0.0038 1.3541
40.6846
0.74833
MDA-MB-436 Vorinostat
HDAC
Misc
2.6793
 0.0330 0.1632 0.0301 1.6566
2.98
0.99632