Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-436 Luminespib
HSP90
Misc
0.0039107
 -0.0492 0.6326 0.0393 3.6046
0.004027
0.999
MDA-MB-436 A-1210477
Mcl-1
Misc
Inf
 0.8728 0.0140 0.0010 0.0000
Inf
0.42977
MDA-MB-436 Olaparib
PARP
Misc
1.536
 0.2383 0.3050 0.0296 0.3132
51.2767
0.98251
MDA-MB-436 Bleomycin
Radiation
Misc
0.85488
 -0.1198 0.3092 0.0484 0.9195
1.4366
0.98079
MDA-MB-436 Ipatasertib
AKT
PI3K/mTOR
25.8679
 0.6111 0.1038 0.0116 0.4073
383.9431
0.92516
MDA-MB-436 Alpelisib
PI3Ka
PI3K/mTOR
36.7582
 0.7252 0.0552 0.0073 0.6026
226.7201
0.84658
MDA-MB-436 Taselisib
PI3Ka, g, d
PI3K/mTOR
4.6563
 0.2431 0.1736 0.0143 0.6355
26.2348
0.92245
MDA-MB-436 TGX221
PI3Kb
PI3K/mTOR
22.0461
 0.7221 0.0019 0.0048 1.3022
18.6589
0.84405
MDA-MB-436 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.041679
 0.1227 0.3390 0.0305 0.6859
0.029409
0.97813
MDA-MB-436 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.6148 0.3144 0.0169 0.7543
0.00065027
0.85083
MDA-MB-436 INK-128
mTORC1/2
PI3K/mTOR
0.024105
 0.2111 0.4295 0.0250 1.0988
0.010706
0.97335
MDA-MB-436 PF-4708671
p70S6K
PI3K/mTOR
4.7528
 0.1938 0.0918 0.0048 1.3212
6.5976
0.98815
MDA-MB-436 Buparlisib
pan PI3K
PI3K/mTOR
1.1815
 -0.2866 0.2925 0.0578 1.6196
1.6556
0.99244
MDA-MB-436 Pictilisib
pan PI3K
PI3K/mTOR
5.2741
 0.2850 0.1328 0.0124 0.7767
21.6999
0.98441
MDA-MB-436 Ceritinib
ALK
RTK
0.49893
 -0.6974 0.4169 0.1006 0.9667
1.4927
0.99602
MDA-MB-436 Neratinib
EGFR/HER2
RTK
0.71562
 0.0162 0.1879 0.0162 0.8626
1.6615
0.98931
MDA-MB-436 Tivantinib
MET
RTK
0.3675
 -0.2711 0.4215 0.0897 2.2220
0.44342
0.99833
MDA-MB-436 Cediranib
VEGFR/cKIT
RTK
3.6098
 -0.3824 0.1610 0.0446 1.8229
6.595
0.98039
MDA-MB-436 Cabozantinib
VEGFR2/MET
RTK
6.5187
 0.0862 0.0592 0.0149 2.1788
10.7014
0.98785
MDA-MB-453 Abemaciclib
CDK4/6
Cell cycle
0.0057723
 -0.7647 0.8495 0.1526 0.2725
0.32512
0.73985
MDA-MB-453 Palbociclib
CDK4/6
Cell cycle
0.042838
 0.0416 0.4402 0.0770 1.2886
0.039852
0.99219
MDA-MB-453 AZD7762
CHK1/2
Cell cycle
0.011509
 -0.2157 0.8564 0.1405 1.6714
0.014102
0.99393
MDA-MB-453 Volasertib
PLK
Cell cycle
0.0071952
 -0.2013 0.5350 0.1191 2.7557
0.0074665
0.98353
MDA-MB-453 Dinaciclib
pan CDK
Cell cycle
0.011359
 -0.2569 0.5807 0.1358 3.4728
0.012824
0.99835
MDA-MB-453 Cisplatin
Chemo
Chemotherapy
3.4106
 0.1328 0.0938 -0.0013 3.0256
3.151
0.9887