Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1937 Buparlisib
pan PI3K
PI3K/mTOR
1.4479
 -0.2256 0.2634 0.0691 1.0878
2.8639
0.99474
HCC1937 Pictilisib
pan PI3K
PI3K/mTOR
2.4235
 0.2784 0.2110 0.0249 0.5947
2.7026
0.99034
HCC1937 Ceritinib
ALK
RTK
3.5257
 -0.5730 0.1368 0.0730 2.2956
5.6897
0.99584
HCC1937 Neratinib
EGFR/HER2
RTK
1.4603
 0.2999 0.1711 0.0289 0.5189
12.13
0.97447
HCC1937 Tivantinib
MET
RTK
0.64919
 -0.0621 0.2925 0.0799 2.1267
0.69626
0.99463
HCC1937 Cediranib
VEGFR/cKIT
RTK
7.9267
 0.2784 0.0440 0.0316 3.5480
8.352
0.99376
HCC1937 Cabozantinib
VEGFR2/MET
RTK
14.4371
 0.7602 0.0053 0.0067 4.9892
11.0339
0.95897
HCC1954 Abemaciclib
CDK4/6
Cell cycle
0.30182
 -0.5049 0.4578 0.0869 0.4867
2.8851
0.937
HCC1954 Palbociclib
CDK4/6
Cell cycle
Inf
 0.5256 0.1839 -0.0048 1.2148
0.056374
0.97285
HCC1954 AZD7762
CHK1/2
Cell cycle
0.12298
 -0.3978 0.5593 0.2944 1.4965
0.1737
0.98591
HCC1954 Volasertib
PLK
Cell cycle
0.0065835
 -0.1540 0.6139 0.2792 3.4968
0.0071308
0.99812
HCC1954 Dinaciclib
pan CDK
Cell cycle
0.012538
 -0.4640 0.6411 0.3049 3.3292
0.015238
0.99808
HCC1954 Cisplatin
Chemo
Chemotherapy
1.2467
 -0.0741 0.2747 0.0807 1.1281
1.7233
0.97383
HCC1954 Doxorubicin
Chemo
Chemotherapy
0.0071835
 -0.3378 0.7296 0.2544 1.4590
0.0086345
0.96869
HCC1954 Taxol
Chemo
Chemotherapy
0.0024667
 -0.3961 0.8347 0.4142 1.6514
0.0034177
0.98666
HCC1954 Topotecan
Topo I
Chemotherapy
0.011912
 -0.4011 0.8695 0.3601 0.7510
0.02452
0.96722
HCC1954 Etoposide
Topo II
Chemotherapy
0.17121
 -0.2651 0.5015 0.2166 0.9804
0.2578
0.98586
HCC1954 Dasatinib
BCR/ABL
MAPK/nRTK
1.9424
 0.2744 0.2026 0.0810 0.7356
1.1887
0.97254
HCC1954 Trametinib
MEK
MAPK/nRTK
0.016729
 0.2287 0.4005 0.0565 0.8524
0.0082359
0.9993
HCC1954 Saracatinib
SRC
MAPK/nRTK
2.1208
 0.0936 0.1939 0.0551 0.7876
4.0749
0.98936
HCC1954 ABT-737
Bcl2/XL
Misc
9.9512
 0.4962 0.0404 0.0618 1.0240
27.9634
0.94601
HCC1954 Vorinostat
HDAC
Misc
1.426
 -0.1401 0.2339 0.0833 1.2390
2.0871
0.99732
HCC1954 Luminespib
HSP90
Misc
0.010331
 -0.3745 0.6188 0.2958 2.6936
0.012628
0.99618
HCC1954 A-1210477
Mcl-1
Misc
Inf
 0.8844 -0.0259 0.0076 0.0000
Inf
0.43063
HCC1954 Olaparib
PARP
Misc
11.1008
 0.5266 0.0536 0.0095 1.2000
8.359
0.96291