Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-453 Doxorubicin
Chemo
Chemotherapy
0.0058313
 -0.3476 0.7915 0.1805 1.7510
0.0071438
0.98132
MDA-MB-453 Taxol
Chemo
Chemotherapy
0.002374
 0.0356 0.6674 0.1683 1.2620
0.0023576
0.81734
MDA-MB-453 Topotecan
Topo I
Chemotherapy
0.0066897
 -0.5289 0.9258 0.1604 1.0131
0.010358
0.92364
MDA-MB-453 Etoposide
Topo II
Chemotherapy
0.38265
 -0.0601 0.3658 0.0418 1.5864
0.41689
0.99692
MDA-MB-453 Dasatinib
BCR/ABL
MAPK/nRTK
11.2977
 0.5486 0.0776 0.0229 1.2179
27.8439
0.76835
MDA-MB-453 Trametinib
MEK
MAPK/nRTK
0.034423
 0.0489 0.3253 0.0542 1.5373
0.031553
0.98454
MDA-MB-453 Saracatinib
SRC
MAPK/nRTK
8.3734
 0.3925 0.0634 0.0273 1.5016
17.4019
0.95549
MDA-MB-453 ABT-737
Bcl2/XL
Misc
5.9702
 0.1516 0.0227 0.0377 4.9881
5.7097
0.9783
MDA-MB-453 Vorinostat
HDAC
Misc
0.9215
 -0.6076 0.3291 0.1421 3.3225
1.1628
0.99512
MDA-MB-453 Luminespib
HSP90
Misc
0.0032643
 -0.4995 0.8803 0.2734 2.6468
0.0042685
0.99671
MDA-MB-453 A-1210477
Mcl-1
Misc
Inf
 0.9330 -0.0364 0.0157 0.0000
Inf
-0.33803
MDA-MB-453 Olaparib
PARP
Misc
1.6695
 -0.0358 0.2414 0.0284 0.7989
4.3612
0.99257
MDA-MB-453 Bleomycin
Radiation
Misc
1.3087
 0.0154 0.2124 0.0259 1.2776
1.4452
0.99022
MDA-MB-453 Ipatasertib
AKT
PI3K/mTOR
0.53911
 -0.1551 0.3144 0.0753 1.3090
0.65666
0.98992
MDA-MB-453 Alpelisib
PI3Ka
PI3K/mTOR
0.53182
 -0.3068 0.3532 0.0861 0.7133
1.648
0.979
MDA-MB-453 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0034639
 -0.6347 1.0079 0.2403 0.8199
0.0064512
0.90769
MDA-MB-453 TGX221
PI3Kb
PI3K/mTOR
15.3342
 0.8281 -0.0281 0.0177 4.9457
12.4514
0.62788
MDA-MB-453 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0083807
 -0.8141 0.6934 0.2249 0.9084
0.023455
0.98046
MDA-MB-453 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.0309 0.8879 0.1169 0.0000
Inf
0.43273
MDA-MB-453 INK-128
mTORC1/2
PI3K/mTOR
0.009907
 -0.4684 0.7631 0.1914 1.6470
0.01349
0.98649
MDA-MB-453 PF-4708671
p70S6K
PI3K/mTOR
4.291
 0.0482 0.0418 0.0294 4.9998
4.2285
0.98022
MDA-MB-453 Buparlisib
pan PI3K
PI3K/mTOR
0.69073
 -0.6073 0.3442 0.1124 1.2215
1.4247
0.9883
MDA-MB-453 Pictilisib
pan PI3K
PI3K/mTOR
0.45409
 -0.3736 0.3924 0.0999 0.7355
1.4609
0.99053
MDA-MB-453 Ceritinib
ALK
RTK
0.36617
 -0.6866 0.4840 0.1577 1.1705
0.84209
0.99139
MDA-MB-453 Neratinib
EGFR/HER2
RTK
0.036055
 -0.3216 0.5532 0.1255 0.4562
0.2347
0.98118