Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC38 Pictilisib
pan PI3K
PI3K/mTOR
6.5531
 0.3569 0.1182 0.0066 0.7184
30.2402
0.97968
HCC38 Ceritinib
ALK
RTK
1.8283
 -0.4039 0.2184 0.0883 2.6153
2.323
0.99573
HCC38 Neratinib
EGFR/HER2
RTK
3.1556
 0.4571 0.1019 0.0168 0.7043
15.0154
0.87632
HCC38 Tivantinib
MET
RTK
0.30919
 -0.2702 0.4367 0.1297 1.8013
0.39141
0.99767
HCC38 Cediranib
VEGFR/cKIT
RTK
1.5907
 -0.2044 0.2096 0.0416 1.0695
3.1564
0.98723
HCC38 Cabozantinib
VEGFR2/MET
RTK
8.2108
 0.3009 0.0376 0.0168 4.3352
8.1748
0.98657
HCC70 Abemaciclib
CDK4/6
Cell cycle
1.885
 -0.8264 0.2315 0.0832 2.5102
2.8439
0.99569
HCC70 Palbociclib
CDK4/6
Cell cycle
Inf
 0.9361 -0.0281 -0.0013 0.0000
Inf
-0.054738
HCC70 AZD7762
CHK1/2
Cell cycle
0.040563
 -0.7002 0.8995 0.3250 2.5054
0.056277
0.99456
HCC70 Volasertib
PLK
Cell cycle
0.0065224
 -0.2049 0.6421 0.1395 3.2698
0.0072379
0.9841
HCC70 Dinaciclib
pan CDK
Cell cycle
0.01286
 -0.9093 0.8338 0.3254 5.0000
0.015807
0.9991
HCC70 Cisplatin
Chemo
Chemotherapy
1.3073
 -0.6832 0.2650 0.0820 1.3165
3.0116
0.99076
HCC70 Doxorubicin
Chemo
Chemotherapy
0.010621
 -0.7794 0.7867 0.1459 2.0410
0.014138
0.93856
HCC70 Taxol
Chemo
Chemotherapy
0.0013411
 -0.5065 0.9773 0.3742 1.1642
0.0024269
0.99734
HCC70 Topotecan
Topo I
Chemotherapy
0.0094575
 -0.8614 1.0593 0.2429 0.6102
0.049603
0.96643
HCC70 Etoposide
Topo II
Chemotherapy
0.36498
 -0.1518 0.4535 0.0513 2.1004
0.41879
0.96872
HCC70 Dasatinib
BCR/ABL
MAPK/nRTK
0.0096376
 -0.5787 1.0609 0.1267 1.0559
0.020015
0.98982
HCC70 Trametinib
MEK
MAPK/nRTK
0.0019047
 -0.0393 0.6924 0.1954 0.8693
0.0021049
0.98467
HCC70 Saracatinib
SRC
MAPK/nRTK
0.063682
 -0.1718 0.5795 0.0595 0.9276
0.081014
0.97522
HCC70 ABT-737
Bcl2/XL
Misc
2.7474
 -0.0638 0.1562 0.0632 0.9362
8.8827
0.97385
HCC70 Vorinostat
HDAC
Misc
0.40578
 -0.4765 0.4082 0.0748 0.8914
1.0253
0.99218
HCC70 Luminespib
HSP90
Misc
0.007646
 -0.5826 0.7792 0.2409 5.0000
0.0088695
0.99752
HCC70 A-1210477
Mcl-1
Misc
Inf
 0.9380 0.0054 0.0123 0.0000
Inf
0.17964
HCC70 Olaparib
PARP
Misc
27.0584
 0.7191 0.0232 -0.0045 0.7530
116.2527
0.78542
HCC70 Bleomycin
Radiation
Misc
0.39804
 -0.1146 0.4192 0.0530 0.9765
0.54995
0.95046