Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC70 Ipatasertib
AKT
PI3K/mTOR
0.1397
 -0.2624 0.4974 0.0860 0.8534
0.21677
0.98567
HCC70 Alpelisib
PI3Ka
PI3K/mTOR
4.4987
 0.0981 0.1182 0.0196 1.0448
12.8744
0.95143
HCC70 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.15092
 -0.6846 0.5796 0.1546 0.7043
0.64661
0.98584
HCC70 TGX221
PI3Kb
PI3K/mTOR
0.092754
 0.0049 0.4729 0.0591 0.8818
0.076452
0.9787
HCC70 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0058452
 -0.5550 0.6451 0.1234 0.5307
0.026938
0.94991
HCC70 Everolimus
mTOR1
PI3K/mTOR
0.24351
 0.3727 0.4764 0.0448 0.1135
51.0339
0.79604
HCC70 INK-128
mTORC1/2
PI3K/mTOR
0.0048011
 -0.1620 0.7024 0.0912 1.1840
0.0050026
0.97794
HCC70 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9348 -0.0227 0.0035 0.0000
Inf
0.040075
HCC70 Buparlisib
pan PI3K
PI3K/mTOR
0.43342
 -0.7274 0.4614 0.1434 1.1927
1.0047
0.99537
HCC70 Pictilisib
pan PI3K
PI3K/mTOR
0.16052
 -0.5972 0.5726 0.1167 0.7256
0.58082
0.99601
HCC70 Ceritinib
ALK
RTK
3.1923
 -0.8808 0.1379 0.0703 5.0000
3.9213
0.99483
HCC70 Neratinib
EGFR/HER2
RTK
0.16013
 0.0595 0.3178 0.0405 1.0555
0.15156
0.99467
HCC70 Tivantinib
MET
RTK
0.3335
 -0.5657 0.4968 0.1515 2.0000
0.48673
0.99617
HCC70 Cediranib
VEGFR/cKIT
RTK
4.5386
 -0.3262 0.0890 0.0440 2.2440
7.4053
0.99062
HCC70 Cabozantinib
VEGFR2/MET
RTK
1.5024
 -0.0911 0.2658 0.0226 0.5892
9.6961
0.92355
PDX1258 Abemaciclib
CDK4/6
Cell cycle
0.67289
 -0.3305 0.3350 0.0542 1.0569
1.2734
0.99626
PDX1258 Palbociclib
CDK4/6
Cell cycle
Inf
 1.0159 -0.0479 0.0014 0.0000
Inf
-18.593
PDX1258 AZD7762
CHK1/2
Cell cycle
0.014946
 -0.4528 0.9199 0.3234 1.6838
0.021221
0.99249
PDX1258 Volasertib
PLK
Cell cycle
0.0073734
 -0.2320 0.5602 0.1765 1.8198
0.0083258
0.98847
PDX1258 Dinaciclib
pan CDK
Cell cycle
0.011566
 -0.6173 0.7036 0.2838 3.5943
0.014366
0.99779
PDX1258 Cisplatin
Chemo
Chemotherapy
2.5568
 0.3181 0.1555 0.0433 1.6027
1.5449
0.99079
PDX1258 Doxorubicin
Chemo
Chemotherapy
0.0091389
 -0.4928 0.7540 0.2368 1.1844
0.013938
0.97567
PDX1258 Taxol
Chemo
Chemotherapy
0.0021522
 -0.0818 0.6797 0.2357 1.2501
0.0022935
0.98829
PDX1258 Topotecan
Topo I
Chemotherapy
0.013472
 -0.4565 0.8673 0.2817 0.8122
0.026852
0.98013
PDX1258 Etoposide
Topo II
Chemotherapy
0.31701
 -0.1807 0.3942 0.1360 1.0906
0.41876
0.99346