Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-453 Tivantinib
MET
RTK
0.20059
 -0.0719 0.4182 0.1017 2.2407
0.20744
0.99393
MDA-MB-453 Cediranib
VEGFR/cKIT
RTK
2.7824
 -0.6894 0.1569 0.0768 3.0858
3.7659
0.99464
MDA-MB-453 Cabozantinib
VEGFR2/MET
RTK
9.0899
 0.4645 -0.0045 0.0208 4.5355
6.5788
0.94161
MDA-MB-468 Abemaciclib
CDK4/6
Cell cycle
2.3386
 -0.2881 0.1766 0.0681 1.5630
3.8065
0.9935
MDA-MB-468 Palbociclib
CDK4/6
Cell cycle
Inf
 1.0457 -0.0214 0.0005 0.0000
Inf
-0.58792
MDA-MB-468 AZD7762
CHK1/2
Cell cycle
0.28495
 -0.5860 0.4932 0.2129 1.0622
0.63742
0.99549
MDA-MB-468 Volasertib
PLK
Cell cycle
0.002104
 -0.4485 0.9279 0.3934 2.9173
0.0026072
0.99938
MDA-MB-468 Dinaciclib
pan CDK
Cell cycle
0.015576
 -0.4131 0.5681 0.1843 2.8840
0.018635
0.99641
MDA-MB-468 Cisplatin
Chemo
Chemotherapy
1.2638
 -0.2866 0.2872 0.0977 1.4057
1.9559
0.99503
MDA-MB-468 Doxorubicin
Chemo
Chemotherapy
0.0054214
 -0.3392 0.9121 0.3191 2.4137
0.0067542
0.99424
MDA-MB-468 Taxol
Chemo
Chemotherapy
0.001354
 -0.5218 1.0076 0.5243 1.2795
0.0023644
0.95471
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
MDA-MB-468 Etoposide
Topo II
Chemotherapy
0.48754
 -0.5132 0.4291 0.1644 1.8475
0.69756
0.99577
MDA-MB-468 Dasatinib
BCR/ABL
MAPK/nRTK
4.4311
 0.3393 0.1447 0.0458 0.7091
5.6436
0.97277
MDA-MB-468 Trametinib
MEK
MAPK/nRTK
0.4421
 0.4075 0.2132 0.0255 0.4592
0.27448
0.99227
MDA-MB-468 Saracatinib
SRC
MAPK/nRTK
4.9591
 0.1778 0.1388 0.0508 0.9811
15.1962
0.9691
MDA-MB-468 ABT-737
Bcl2/XL
Misc
6.0269
 0.1420 0.0860 0.0547 1.5887
12.0342
0.98897
MDA-MB-468 Vorinostat
HDAC
Misc
1.5734
 -0.1191 0.2172 0.0608 1.9840
1.8053
0.99971
MDA-MB-468 Luminespib
HSP90
Misc
0.0048347
 -0.1738 0.6478 0.1563 4.7025
0.0051177
0.99878
MDA-MB-468 A-1210477
Mcl-1
Misc
Inf
 0.9299 0.0206 0.0057 0.3898
963.6809
0.60314
MDA-MB-468 Olaparib
PARP
Misc
7.9202
 0.3408 0.0576 0.0179 1.6505
15.4105
0.98176
MDA-MB-468 Bleomycin
Radiation
Misc
0.82322
 -0.2103 0.3246 0.1050 0.8733
1.7869
0.99409
MDA-MB-468 Ipatasertib
AKT
PI3K/mTOR
2.3697
 0.3091 0.2229 0.0266 0.5702
1.4742
0.96355
MDA-MB-468 Alpelisib
PI3Ka
PI3K/mTOR
15.9683
 0.7142 0.0314 0.0171 1.4955
33.2195
0.92719
MDA-MB-468 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.3526
 0.0046 0.2170 0.0736 0.6960
11.4039
0.97997