Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-468 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7230 0.1032 0.0343 0.5264
0.7426
0.94963
MDA-MB-468 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.016032
 -0.0415 0.4371 0.1010 0.9482
0.015849
0.98843
MDA-MB-468 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.5275 0.4288 0.0743 0.2018
1.1048e-05
0.70612
MDA-MB-468 INK-128
mTORC1/2
PI3K/mTOR
0.023529
 0.0573 0.5025 0.1038 1.2151
0.020647
0.99651
MDA-MB-468 PF-4708671
p70S6K
PI3K/mTOR
4.1732
 0.0813 0.1176 0.0094 1.1782
8.8804
0.99743
MDA-MB-468 Buparlisib
pan PI3K
PI3K/mTOR
0.83168
 -0.5157 0.3573 0.2010 2.1267
1.1738
0.99824
MDA-MB-468 Pictilisib
pan PI3K
PI3K/mTOR
2.3306
 -0.0613 0.2054 0.0776 0.7959
9.2675
0.99096
MDA-MB-468 Ceritinib
ALK
RTK
0.76749
 -0.7415 0.4050 0.1730 1.6622
1.3833
0.99574
MDA-MB-468 Neratinib
EGFR/HER2
RTK
0.15781
 -0.3825 0.3861 0.1513 0.8303
0.41607
0.99579
MDA-MB-468 Tivantinib
MET
RTK
0.30706
 -0.4549 0.4903 0.2341 2.9835
0.37002
0.99499
MDA-MB-468 Cediranib
VEGFR/cKIT
RTK
3.9154
 -0.7083 0.1649 0.0970 3.0423
5.6183
0.9962
MDA-MB-468 Cabozantinib
VEGFR2/MET
RTK
8.9681
 0.4233 0.0441 0.0115 1.7711
16.6732
0.9812
CAL-51 Abemaciclib
CDK4/6
Cell cycle
0.11268
 -0.4637 0.5776 0.0890 0.4136
1.605
0.97536
CAL-51 Palbociclib
CDK4/6
Cell cycle
0.37241
 0.3607 0.2498 -0.0215 0.8353
0.084749
0.99265
CAL-51 AZD7762
CHK1/2
Cell cycle
0.044603
 -0.5186 0.7151 0.2631 1.2331
0.070405
0.98322
CAL-51 Volasertib
PLK
Cell cycle
0.0059136
 -0.3372 0.6787 0.2411 3.0715
0.0068268
0.99697
CAL-51 Dinaciclib
pan CDK
Cell cycle
0.014709
 -0.3585 0.5985 0.2374 3.5319
0.017105
0.99939
CAL-51 Cisplatin
Chemo
Chemotherapy
2.0989
 -0.0329 0.2145 0.0322 0.9070
4.8677
0.9969
CAL-51 Doxorubicin
Chemo
Chemotherapy
0.0085841
 -0.4803 0.7954 0.2347 1.0881
0.014188
0.98761
CAL-51 Taxol
Chemo
Chemotherapy
0.004167
 -0.2200 0.6694 0.1963 1.3689
0.0053072
0.99639
CAL-51 Topotecan
Topo I
Chemotherapy
0.019146
 -0.5303 0.8558 0.2745 1.1807
0.031097
0.97872
CAL-51 Etoposide
Topo II
Chemotherapy
0.24029
 -0.2097 0.4669 0.0707 1.1885
0.32971
0.99772
CAL-51 Dasatinib
BCR/ABL
MAPK/nRTK
0.058089
 0.0983 0.5161 0.1625 0.8670
0.042316
0.9975
CAL-51 Trametinib
MEK
MAPK/nRTK
Inf
 0.7064 0.0662 0.0124 0.8944
0.19105
0.98439
CAL-51 Saracatinib
SRC
MAPK/nRTK
1.8499
 0.2582 0.2271 0.0547 0.6810
1.6055
0.99804