Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAL-85-1 | Abemaciclib | CDK4/6 | Cell cycle | 1.3003 | -0.2236 | 0.2357 | 0.0485 | 2.1239 | 1.5776 | 0.99317 |
| CAL-85-1 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0418 | -0.0009 | 0.0000 | Inf | -4.681 |
| CAL-85-1 | AZD7762 | CHK1/2 | Cell cycle | 0.040606 | -0.3218 | 0.7076 | 0.2631 | 1.6067 | 0.053833 | 0.98746 |
| CAL-85-1 | Volasertib | PLK | Cell cycle | 0.0032652 | -0.2891 | 0.7316 | 0.1652 | 2.0442 | 0.0039314 | 0.99429 |
| CAL-85-1 | Dinaciclib | pan CDK | Cell cycle | 0.0046904 | -0.2406 | 0.6880 | 0.1122 | 2.1120 | 0.005589 | 0.99744 |
| CAL-85-1 | Cisplatin | Chemo | Chemotherapy | 1.0309 | 0.0180 | 0.2294 | 0.0709 | 1.5157 | 1.0419 | 0.99209 |
| CAL-85-1 | Doxorubicin | Chemo | Chemotherapy | 0.0055249 | -0.3783 | 0.8476 | 0.2160 | 1.2228 | 0.008362 | 0.98762 |
| CAL-85-1 | Taxol | Chemo | Chemotherapy | 0.0027273 | -0.3464 | 0.7931 | 0.3351 | 2.0210 | 0.0033785 | 0.95638 |
| CAL-85-1 | Topotecan | Topo I | Chemotherapy | 0.015768 | -0.2957 | 0.8426 | 0.2732 | 1.2311 | 0.02233 | 0.99293 |
| CAL-85-1 | Etoposide | Topo II | Chemotherapy | 0.41623 | -0.2411 | 0.4065 | 0.1218 | 1.3731 | 0.57431 | 0.99814 |
| CAL-85-1 | Dasatinib | BCR/ABL | MAPK/nRTK | 0.10548 | -0.2438 | 0.5705 | 0.2154 | 1.9425 | 0.12743 | 0.99128 |
| CAL-85-1 | Trametinib | MEK | MAPK/nRTK | 0.013202 | 0.2343 | 0.4101 | 0.1186 | 0.9630 | 0.007054 | 0.99004 |
| CAL-85-1 | Saracatinib | SRC | MAPK/nRTK | 0.87395 | 0.1156 | 0.2171 | 0.0941 | 1.9351 | 0.73844 | 0.98771 |
| CAL-85-1 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9343 | -0.0283 | 0.0138 | 0.0000 | Inf | -0.025903 |
| CAL-85-1 | Vorinostat | HDAC | Misc | 1.1999 | -0.1827 | 0.2194 | 0.0392 | 1.8241 | 1.4346 | 0.98796 |
| CAL-85-1 | Luminespib | HSP90 | Misc | 0.006517 | -0.3836 | 0.7497 | 0.3002 | 4.8089 | 0.0073269 | 0.99963 |
| CAL-85-1 | A-1210477 | Mcl-1 | Misc | Inf | 1.0052 | 0.0109 | 0.0047 | 0.0000 | Inf | 0.20764 |
| CAL-85-1 | Olaparib | PARP | Misc | 5.0606 | 0.3870 | 0.1367 | 0.0158 | 0.7846 | 3.2235 | 0.97652 |
| CAL-85-1 | Bleomycin | Radiation | Misc | 0.45343 | -0.1075 | 0.3850 | 0.1072 | 0.7086 | 0.91411 | 0.99198 |
| CAL-85-1 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.4714 | 0.1662 | -0.0047 | 1.3900 | 0.27338 | 0.96561 |
| CAL-85-1 | Alpelisib | PI3Ka | PI3K/mTOR | 3.6425 | 0.2928 | 0.1938 | 0.0110 | 0.4506 | 41.7026 | 0.9641 |
| CAL-85-1 | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.06039 | -0.0171 | 0.5499 | 0.0664 | 0.4393 | 0.084981 | 0.97865 |
| CAL-85-1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9895 | -0.0309 | 0.0002 | 0.0000 | Inf | -1.0218 |
| CAL-85-1 | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.0086205 | -0.1543 | 0.5396 | 0.0780 | 0.8828 | 0.01093 | 0.99167 |
| CAL-85-1 | Everolimus | mTOR1 | PI3K/mTOR | 0.0015471 | 0.3707 | 0.5762 | 0.0915 | 5.0000 | 0.0011149 | 0.86907 |