Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HME1 Saracatinib
SRC
MAPK/nRTK
7.2253
 0.4596 0.0026 0.0041 5.0000
4.583
0.94329
HME1 ABT-737
Bcl2/XL
Misc
Inf
 0.4949 0.0896 0.0303 5.0000
1.1036
0.96879
HME1 Vorinostat
HDAC
Misc
3.0223
 0.0551 0.1529 0.0150 1.2382
4.3407
0.99434
HME1 Luminespib
HSP90
Misc
0.0085459
 -0.3346 0.6544 0.3132 5.0000
0.0094546
0.99721
HME1 A-1210477
Mcl-1
Misc
0.89942
 -0.4222 0.3385 0.1394 2.8064
1.1273
0.99868
HME1 Olaparib
PARP
Misc
25.4252
 0.5911 0.0258 -0.0009 1.9303
5.1651
0.96396
HME1 Bleomycin
Radiation
Misc
0.20687
 -0.1105 0.4801 0.1073 0.8989
0.29746
0.98718
HME1 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.6353 0.0365 0.0079 1.2722
3.6876
0.93611
HME1 Alpelisib
PI3Ka
PI3K/mTOR
6.0356
 0.3071 0.1123 0.0079 0.9018
20.4027
0.98253
HME1 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.14812
 0.0336 0.4394 0.0340 0.8119
0.13524
0.98597
HME1 TGX221
PI3Kb
PI3K/mTOR
Inf
 1.0265 -0.0318 -0.0005 0.0000
Inf
-0.12868
HME1 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.025621
 0.0764 0.3468 0.0310 1.0824
0.018946
0.97645
HME1 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.4888 0.3716 0.0206 0.0000
Inf
0.05647
HME1 INK-128
mTORC1/2
PI3K/mTOR
0.033475
 0.1969 0.4005 0.0164 1.3589
0.020278
0.99162
HME1 PF-4708671
p70S6K
PI3K/mTOR
5.3765
 0.4546 0.1358 0.0746 1.1002
0.7834
0.96742
HME1 Buparlisib
pan PI3K
PI3K/mTOR
1.1504
 -0.2416 0.2469 0.0826 1.9615
1.4311
0.99598
HME1 Pictilisib
pan PI3K
PI3K/mTOR
2.8093
 0.1260 0.1418 0.0078 1.0287
3.8551
0.98326
HME1 Ceritinib
ALK
RTK
0.82116
 -0.3557 0.3036 0.1273 1.8255
1.1186
0.99521
HME1 Neratinib
EGFR/HER2
RTK
0.15243
 0.0983 0.2773 0.0166 1.3397
0.11637
0.9808
HME1 Tivantinib
MET
RTK
0.034438
 -0.1612 0.6592 0.2212 2.3055
0.037958
0.99175
HME1 Cediranib
VEGFR/cKIT
RTK
7.6446
 0.0275 0.0214 0.0244 4.8856
8.7954
0.98095
HME1 Cabozantinib
VEGFR2/MET
RTK
3.2402
 -0.1052 0.1020 0.0260 2.6885
3.6278
0.98973
SUM1315MO2 Abemaciclib
CDK4/6
Cell cycle
0.049304
 -0.1445 0.5815 0.0291 0.5067
0.075697
0.94514
SUM1315MO2 Palbociclib
CDK4/6
Cell cycle
0.093193
 0.3001 0.3314 0.0115 0.9738
0.030153
0.98295
SUM1315MO2 AZD7762
CHK1/2
Cell cycle
0.050295
 -0.6526 0.7008 0.2071 0.9510
0.10294
0.9607