Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM1315MO2 Volasertib
PLK
Cell cycle
0.0095
 -0.3877 0.6658 0.2263 2.3240
0.012143
0.99552
SUM1315MO2 Dinaciclib
pan CDK
Cell cycle
0.010938
 -0.6674 0.7696 0.2780 4.1442
0.013399
0.99826
SUM1315MO2 Cisplatin
Chemo
Chemotherapy
1.275
 0.2028 0.2961 0.0592 0.4798
3.6243
0.95111
SUM1315MO2 Doxorubicin
Chemo
Chemotherapy
0.018222
 -0.0635 0.5132 0.1324 2.0980
0.016338
0.96491
SUM1315MO2 Taxol
Chemo
Chemotherapy
0.0024623
 -0.3258 0.7931 0.2940 2.0093
0.0030737
0.99498
SUM1315MO2 Topotecan
Topo I
Chemotherapy
0.011771
 -0.3317 0.7690 0.2174 0.3263
0.11949
0.94357
SUM1315MO2 Etoposide
Topo II
Chemotherapy
0.29244
 0.0416 0.3833 0.1087 0.7536
0.26458
0.97369
SUM1315MO2 Dasatinib
BCR/ABL
MAPK/nRTK
0.019122
 -0.2366 0.7398 0.1323 0.4601
0.063919
0.98963
SUM1315MO2 Trametinib
MEK
MAPK/nRTK
0.021115
 0.1329 0.3887 0.0532 1.0540
0.01638
0.99458
SUM1315MO2 Saracatinib
SRC
MAPK/nRTK
1.3921
 0.0846 0.2439 0.0407 0.7066
2.4563
0.99551
SUM1315MO2 ABT-737
Bcl2/XL
Misc
5.9406
 0.3056 0.0987 0.0360 0.8016
23.3924
0.93756
SUM1315MO2 Vorinostat
HDAC
Misc
1.7621
 -0.0668 0.1742 0.0660 2.7811
1.8526
0.9927
SUM1315MO2 Luminespib
HSP90
Misc
0.0048627
 -0.0810 0.6112 0.1374 5.0000
0.0050309
0.99738
SUM1315MO2 A-1210477
Mcl-1
Misc
Inf
 0.7399 -0.0234 -0.0009 3.9393
9.1387
0.79269
SUM1315MO2 Olaparib
PARP
Misc
2.0295
 0.0911 0.2452 0.0432 0.5075
17.6824
0.94995
SUM1315MO2 Bleomycin
Radiation
Misc
0.21351
 0.1491 0.4103 0.1246 0.8125
0.15089
0.9779
SUM1315MO2 Ipatasertib
AKT
PI3K/mTOR
36.6304
 0.6070 0.1242 0.0099 0.3263
999.2697
0.9146
SUM1315MO2 Alpelisib
PI3Ka
PI3K/mTOR
6.462
 0.3829 0.1169 0.0203 0.5997
40.3568
0.94056
SUM1315MO2 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.51622
 0.0942 0.3970 0.0476 0.2926
22.0638
0.995
SUM1315MO2 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7054 0.1362 0.0073 0.9367
0.077385
0.83645
SUM1315MO2 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.015037
 -0.0903 0.4863 0.0621 0.7079
0.022637
0.99665
SUM1315MO2 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.4018 0.4539 0.0330 0.0000
Inf
0.42807
SUM1315MO2 INK-128
mTORC1/2
PI3K/mTOR
0.0065863
 0.0256 0.6471 0.0662 0.8616
0.0061137
0.99691
SUM1315MO2 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.5951 0.0977 0.0059 0.9518
1.3643
0.93531
SUM1315MO2 Buparlisib
pan PI3K
PI3K/mTOR
0.40124
 -0.3686 0.4388 0.1149 0.9148
0.94031
0.98014