Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM1315MO2 Pictilisib
pan PI3K
PI3K/mTOR
0.51112
 0.1300 0.3707 0.0433 0.4384
0.96851
0.98439
SUM1315MO2 Ceritinib
ALK
RTK
0.6688
 -0.7650 0.4135 0.0975 1.0318
1.9396
0.99439
SUM1315MO2 Neratinib
EGFR/HER2
RTK
0.092366
 0.1140 0.3661 0.0353 0.9382
0.073122
0.99266
SUM1315MO2 Tivantinib
MET
RTK
0.36967
 -0.4300 0.4751 0.1718 2.1700
0.49553
0.9978
SUM1315MO2 Cediranib
VEGFR/cKIT
RTK
1.4839
 -0.2276 0.2430 0.0500 0.7936
5.924
0.99038
SUM1315MO2 Cabozantinib
VEGFR2/MET
RTK
4.5316
 0.1095 0.1089 0.0163 1.1058
12.2361
0.99069
SUM159PT Abemaciclib
CDK4/6
Cell cycle
0.28398
 -0.4677 0.4585 0.1015 0.4799
2.802
0.95259
SUM159PT Palbociclib
CDK4/6
Cell cycle
1.1058
 0.3876 0.1990 -0.0006 0.6326
0.40763
0.99661
SUM159PT AZD7762
CHK1/2
Cell cycle
0.81589
 -0.1124 0.2697 0.0926 1.5031
0.93462
0.99443
SUM159PT Volasertib
PLK
Cell cycle
0.024832
 0.0468 0.3873 0.1208 3.5660
0.024055
0.99966
SUM159PT Dinaciclib
pan CDK
Cell cycle
0.016967
 -0.0646 0.4536 0.1030 5.0000
0.017277
0.99948
SUM159PT Cisplatin
Chemo
Chemotherapy
5.2539
 0.1742 0.1149 0.0416 1.1412
13.758
0.99717
SUM159PT Doxorubicin
Chemo
Chemotherapy
0.019121
 -0.2740 0.6068 0.2965 1.5857
0.022541
0.98806
SUM159PT Taxol
Chemo
Chemotherapy
0.0047473
 -0.1485 0.6380 0.2976 2.2238
0.0052544
0.99906
SUM159PT Topotecan
Topo I
Chemotherapy
0.019593
 -0.3284 0.7927 0.3329 1.4860
0.025267
0.97848
SUM159PT Etoposide
Topo II
Chemotherapy
0.41904
 -0.1489 0.3736 0.1389 1.7468
0.47824
0.99862
SUM159PT Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.5642 0.1850 0.0047 1.3689
0.14044
0.98104
SUM159PT Trametinib
MEK
MAPK/nRTK
0.0055877
 0.2792 0.4613 0.0039 0.9923
0.0023029
0.99862
SUM159PT Saracatinib
SRC
MAPK/nRTK
13.9057
 0.5624 0.0724 -0.0011 0.9804
8.3037
0.99931
SUM159PT ABT-737
Bcl2/XL
Misc
14.892
 0.6822 0.0239 0.0074 1.9362
14.743
0.99356
SUM159PT Vorinostat
HDAC
Misc
1.9985
 0.1195 0.1810 0.0216 1.3229
1.9352
0.99956
SUM159PT Luminespib
HSP90
Misc
0.0063084
 -0.0476 0.5743 0.2156 4.5596
0.0064127
0.9997
SUM159PT A-1210477
Mcl-1
Misc
15.1726
 0.7796 0.0000 0.0026 4.9964
11.2086
0.95671
SUM159PT Olaparib
PARP
Misc
18.3192
 0.7244 0.0350 0.0011 1.2272
44.7404
0.98618
SUM159PT Bleomycin
Radiation
Misc
0.28119
 -0.0577 0.4191 0.1680 0.7700
0.38984
0.99881