Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1143 A-1210477
Mcl-1
Misc
16.3987
 0.6719 0.0640 0.0008 1.0821
44.847
0.81227
HCC1143 Olaparib
PARP
Misc
8.8262
 0.4562 0.0925 0.0158 0.7545
37.8573
0.98047
HCC1143 Bleomycin
Radiation
Misc
0.04818
 -0.2085 0.6578 0.1955 1.0629
0.066427
0.9974
HCC1143 Ipatasertib
AKT
PI3K/mTOR
80.6794
 0.7509 0.0662 -0.0023 0.4354
999.9134
0.83579
HCC1143 Alpelisib
PI3Ka
PI3K/mTOR
9.8836
 0.4797 0.1743 0.0189 0.3582
212.3193
0.93833
HCC1143 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.21535
 -0.0942 0.4758 0.0890 0.3239
6.4012
0.99147
HCC1143 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9185 0.0347 0.0040 4.9981
0.020639
0.76284
HCC1143 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.044657
 -0.1535 0.3642 0.0851 1.0643
0.061723
0.99242
HCC1143 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.5574 0.3426 0.0295 0.1006
0.071342
0.79962
HCC1143 INK-128
mTORC1/2
PI3K/mTOR
0.04046
 0.0314 0.4743 0.0660 0.7035
0.039906
0.9903
HCC1143 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.7394 0.0639 0.0042 0.6101
17.8472
0.96209
HCC1143 Buparlisib
pan PI3K
PI3K/mTOR
0.7249
 -0.4360 0.3915 0.1265 1.3299
1.2866
0.98685
HCC1143 Pictilisib
pan PI3K
PI3K/mTOR
0.97831
 -0.1291 0.3201 0.0583 0.5213
8.0489
0.97859
HCC1143 Ceritinib
ALK
RTK
1.4479
 -0.4219 0.2848 0.0621 1.0347
4.1868
0.99172
HCC1143 Neratinib
EGFR/HER2
RTK
0.67229
 0.0791 0.2379 0.0489 0.5527
4.9078
0.98415
HCC1143 Tivantinib
MET
RTK
0.27789
 -0.3122 0.4977 0.1369 1.9433
0.35725
0.99341
HCC1143 Cediranib
VEGFR/cKIT
RTK
3.7314
 0.0093 0.1653 0.0292 1.0590
10.5294
0.98332
HCC1143 Cabozantinib
VEGFR2/MET
RTK
10.6105
 0.5122 0.1025 0.0156 0.9383
34.2157
0.84631
PDXHCI002 Abemaciclib
CDK4/6
Cell cycle
0.047944
 -0.6767 0.7662 0.1664 0.6873
0.18848
0.98885
PDXHCI002 Palbociclib
CDK4/6
Cell cycle
0.12955
 0.2766 0.2793 -0.0122 1.1851
0.053617
0.97783
PDXHCI002 AZD7762
CHK1/2
Cell cycle
0.067995
 -0.5815 0.7079 0.2347 0.8162
0.19222
0.98921
PDXHCI002 Volasertib
PLK
Cell cycle
0.0037003
 -0.5892 0.8480 0.3925 4.6276
0.0042869
0.99531
PDXHCI002 Dinaciclib
pan CDK
Cell cycle
0.012194
 -0.3607 0.6030 0.2029 4.6252
0.01372
0.99728
PDXHCI002 Cisplatin
Chemo
Chemotherapy
1.7306
 -0.0985 0.2044 -0.0257 1.2874
2.4053
0.98631
PDXHCI002 Doxorubicin
Chemo
Chemotherapy
0.0040539
 -0.6545 0.9685 0.2951 0.9297
0.0087544
0.98094