Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1428 Taselisib
PI3Ka, g, d
PI3K/mTOR
4.2249
 0.1734 0.1438 0.0192 0.8693
14.9521
0.96527
HCC1428 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7695 0.0143 0.0033 4.9999
3.7973
0.75865
HCC1428 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.012745
 -0.0145 0.4463 0.0566 1.2300
0.012006
0.9876
HCC1428 Everolimus
mTOR1
PI3K/mTOR
0.031039
 0.3462 0.5186 0.0192 0.1000
0.0006981
0.70927
HCC1428 INK-128
mTORC1/2
PI3K/mTOR
0.0059301
 -0.0001 0.6483 0.0519 1.1926
0.0053821
0.98873
HCC1428 PF-4708671
p70S6K
PI3K/mTOR
69.2764
 0.8643 -0.0019 -0.0001 0.8694
128.134
0.60897
HCC1428 Buparlisib
pan PI3K
PI3K/mTOR
0.69074
 -0.2646 0.3524 0.1087 1.9122
0.88637
0.99206
HCC1428 Pictilisib
pan PI3K
PI3K/mTOR
5.8689
 0.1916 0.1171 0.0310 1.2411
14.2229
0.90007
HCC1428 Ceritinib
ALK
RTK
1.2414
 -0.8673 0.3014 0.1288 1.6178
2.4481
0.99584
HCC1428 Neratinib
EGFR/HER2
RTK
1.4327
 -0.0412 0.1042 0.0283 1.5482
2.7752
0.9933
HCC1428 Tivantinib
MET
RTK
0.2516
 0.0341 0.3664 0.1106 2.2041
0.23715
0.99573
HCC1428 Cediranib
VEGFR/cKIT
RTK
3.1657
 -0.5502 0.1943 0.0619 1.9637
5.5392
0.98192
HCC1428 Cabozantinib
VEGFR2/MET
RTK
Inf
 0.6310 0.0204 -0.0008 2.9241
4.2982
0.94377
HME1 Abemaciclib
CDK4/6
Cell cycle
0.19935
 0.0156 0.4285 0.0217 0.6437
0.22196
0.98583
HME1 Palbociclib
CDK4/6
Cell cycle
0.22285
 0.2572 0.2611 0.0111 0.9777
0.10881
0.98803
HME1 AZD7762
CHK1/2
Cell cycle
0.2501
 -0.4780 0.4638 0.2260 1.0093
0.48873
0.98439
HME1 Volasertib
PLK
Cell cycle
0.017242
 -0.0817 0.4263 0.1273 3.6204
0.017483
0.99425
HME1 Dinaciclib
pan CDK
Cell cycle
0.012053
 -0.2848 0.5701 0.2465 5.0000
0.013188
0.9972
HME1 Cisplatin
Chemo
Chemotherapy
1.1201
 -0.2180 0.2969 0.0782 0.8418
3.0767
0.99525
HME1 Doxorubicin
Chemo
Chemotherapy
0.0047147
 -0.3985 0.8359 0.2785 0.9521
0.0078037
0.96003
HME1 Taxol
Chemo
Chemotherapy
0.0031675
 -0.2241 0.6794 0.2401 1.5314
0.0037399
0.98563
HME1 Topotecan
Topo I
Chemotherapy
0.0072669
 -0.3399 0.8727 0.2534 1.2621
0.0091245
0.95352
HME1 Etoposide
Topo II
Chemotherapy
0.13797
 -0.3838 0.5421 0.1754 1.3297
0.19469
0.98888
HME1 Dasatinib
BCR/ABL
MAPK/nRTK
0.18336
 -0.0749 0.4174 0.0505 1.1864
0.19403
0.97949
HME1 Trametinib
MEK
MAPK/nRTK
0.0057339
 0.2032 0.4387 0.0257 2.4280
0.0044228
0.99436