Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAMA-1 Neratinib
EGFR/HER2
RTK
2.8315
 0.4493 0.0703 0.0063 1.1466
7.3732
0.99027
CAMA-1 Tivantinib
MET
RTK
0.27573
 -0.5655 0.5259 0.2061 2.2178
0.36921
0.99228
CAMA-1 Cediranib
VEGFR/cKIT
RTK
5.0236
 -0.2923 0.1089 0.0448 2.4671
7.8416
0.99299
CAMA-1 Cabozantinib
VEGFR2/MET
RTK
8.7107
 0.2436 0.0342 0.0090 4.9963
10.1282
0.97965
HCC1428 Abemaciclib
CDK4/6
Cell cycle
0.0097947
 0.0492 0.6359 0.0146 0.9863
0.0062766
0.95101
HCC1428 Palbociclib
CDK4/6
Cell cycle
0.074657
 0.2542 0.3272 0.0037 1.4145
0.043222
0.98733
HCC1428 AZD7762
CHK1/2
Cell cycle
0.39126
 -0.2152 0.3761 0.0843 1.2225
0.55117
0.98948
HCC1428 Volasertib
PLK
Cell cycle
0.018634
 -0.0388 0.4063 0.0917 2.1456
0.018507
0.99276
HCC1428 Dinaciclib
pan CDK
Cell cycle
0.017078
 -0.6716 0.6610 0.2408 2.9825
0.02239
0.9979
HCC1428 Cisplatin
Chemo
Chemotherapy
0.91164
 0.1223 0.2655 0.0096 1.2004
0.80529
0.9803
HCC1428 Doxorubicin
Chemo
Chemotherapy
0.0047408
 -0.7396 0.8955 0.2242 0.5182
0.029971
0.95944
HCC1428 Taxol
Chemo
Chemotherapy
0.0086248
 0.0645 0.5066 0.2045 0.7260
0.0074214
0.91451
HCC1428 Topotecan
Topo I
Chemotherapy
0.010613
 -0.3764 0.8345 0.1405 0.6324
0.02202
0.8529
HCC1428 Etoposide
Topo II
Chemotherapy
0.21399
 -0.0320 0.4009 0.0511 1.7833
0.20625
0.98346
HCC1428 Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.5784 0.2562 0.0192 0.6681
0.040103
0.94117
HCC1428 Trametinib
MEK
MAPK/nRTK
Inf
 0.8152 0.0767 0.0025 5.0000
0.024413
0.9037
HCC1428 Saracatinib
SRC
MAPK/nRTK
Inf
 0.6691 0.0697 0.0076 0.8735
1.6565
0.94133
HCC1428 ABT-737
Bcl2/XL
Misc
4.0616
 0.2431 0.1194 0.0716 1.0222
5.0858
0.98165
HCC1428 Vorinostat
HDAC
Misc
0.83512
 -0.4792 0.3399 0.1022 1.4868
1.371
0.99679
HCC1428 Luminespib
HSP90
Misc
0.0028629
 -0.0043 0.6375 0.0972 5.0000
0.0028677
0.99886
HCC1428 A-1210477
Mcl-1
Misc
Inf
 0.8155 -0.0207 0.0026 4.9615
5.2131
0.71606
HCC1428 Olaparib
PARP
Misc
0.55326
 0.1185 0.3229 0.0089 0.8769
0.48774
0.98952
HCC1428 Bleomycin
Radiation
Misc
4.2581
 0.2173 0.1780 0.0166 0.7393
18.8191
0.91689
HCC1428 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.9911 -0.0383 -0.0001 0.0000
Inf
-2.9826
HCC1428 Alpelisib
PI3Ka
PI3K/mTOR
Inf
 0.8530 0.0202 0.0031 0.0000
Inf
0.41688