Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1954 Bleomycin
Radiation
Misc
0.043847
 -0.0884 0.6166 0.2476 0.7506
0.05535
0.98102
HCC1954 Ipatasertib
AKT
PI3K/mTOR
1.4342
 0.2509 0.2145 0.0288 0.9249
0.80694
0.98539
HCC1954 Alpelisib
PI3Ka
PI3K/mTOR
1.2292
 -0.3408 0.2652 0.1073 0.8509
4.4679
0.99224
HCC1954 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0070107
 -0.3632 0.9490 0.3748 1.0954
0.010784
0.99379
HCC1954 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9607 -0.0374 -0.0050 0.0000
Inf
-1.0282
HCC1954 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0096629
 -0.3280 0.5536 0.1704 0.7380
0.018218
0.98125
HCC1954 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.3263 0.6531 0.1358 0.0000
Inf
0.52018
HCC1954 INK-128
mTORC1/2
PI3K/mTOR
0.014251
 -0.0830 0.5651 0.1455 1.3479
0.013876
0.98856
HCC1954 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.8349 -0.0093 -0.0064 1.3800
7.2097
0.65841
HCC1954 Buparlisib
pan PI3K
PI3K/mTOR
0.52073
 -0.4576 0.4002 0.1883 1.6194
0.7982
0.9975
HCC1954 Pictilisib
pan PI3K
PI3K/mTOR
0.94449
 -0.2272 0.3087 0.1077 0.8502
2.3595
0.9976
HCC1954 Ceritinib
ALK
RTK
2.3105
 -0.4446 0.1668 0.0701 2.4217
3.1138
0.99363
HCC1954 Neratinib
EGFR/HER2
RTK
0.067164
 -0.0909 0.4293 0.1185 0.6344
0.096489
0.97441
HCC1954 Tivantinib
MET
RTK
0.16715
 -0.3846 0.5511 0.2533 1.4818
0.24265
0.99675
HCC1954 Cediranib
VEGFR/cKIT
RTK
4.092
 -0.3202 0.0756 0.0534 4.9589
4.5507
0.99308
HCC1954 Cabozantinib
VEGFR2/MET
RTK
10.9106
 0.6390 -0.0135 -0.0074 5.0000
13.0234
0.87916
CAL-120 Abemaciclib
CDK4/6
Cell cycle
0.247
 -0.1408 0.4780 0.0849 0.3730
4.696
0.95026
CAL-120 Palbociclib
CDK4/6
Cell cycle
Inf
 0.6687 0.1422 0.0012 1.4451
0.023318
0.96675
CAL-120 AZD7762
CHK1/2
Cell cycle
0.15216
 -0.4949 0.5265 0.2150 1.1035
0.26511
0.97495
CAL-120 Volasertib
PLK
Cell cycle
0.0018536
 0.0258 0.6758 0.2649 2.5191
0.001844
0.99276
CAL-120 Dinaciclib
pan CDK
Cell cycle
0.009892
 -0.1320 0.5549 0.1203 4.4157
0.010404
0.99947
CAL-120 Cisplatin
Chemo
Chemotherapy
2.9328
 0.1876 0.1824 0.0229 0.9231
4.0426
0.98856
CAL-120 Doxorubicin
Chemo
Chemotherapy
0.009438
 -0.2475 0.6969 0.1356 1.3775
0.011488
0.99278
CAL-120 Taxol
Chemo
Chemotherapy
0.0028769
 -0.1987 0.7463 0.3104 2.6390
0.0032354
0.97877
CAL-120 Topotecan
Topo I
Chemotherapy
0.007493
 -0.3364 0.9130 0.2556 1.1649
0.010414
0.97973