Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAL-51 ABT-737
Bcl2/XL
Misc
30.4739
 0.8756 0.0125 0.0091 1.7501
30.7264
0.93007
CAL-51 Vorinostat
HDAC
Misc
1.8294
 -0.0506 0.1862 0.0337 1.4510
2.2081
0.98967
CAL-51 Luminespib
HSP90
Misc
0.0063934
 -0.3386 0.7043 0.2784 3.0050
0.0075437
0.9995
CAL-51 A-1210477
Mcl-1
Misc
Inf
 0.9919 0.0073 0.0004 0.0000
Inf
0.00046652
CAL-51 Olaparib
PARP
Misc
7.1917
 0.3596 0.1163 0.0073 0.8214
27.3972
0.94373
CAL-51 Bleomycin
Radiation
Misc
0.1694
 -0.1344 0.4855 0.0479 0.8490
0.24736
0.9994
CAL-51 Ipatasertib
AKT
PI3K/mTOR
2.978
 0.3866 0.2238 0.0226 0.5898
0.68363
0.98798
CAL-51 Alpelisib
PI3Ka
PI3K/mTOR
6.1028
 0.3436 0.1490 0.0190 0.5874
39.608
0.96055
CAL-51 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.13353
 -0.4129 0.5460 0.1721 0.4106
1.9394
0.97937
CAL-51 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9105 -0.0094 0.0003 0.0000
Inf
0.56048
CAL-51 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.017867
 -0.1520 0.4562 0.1029 0.8686
0.02383
0.99351
CAL-51 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.5477 0.4319 0.0326 1.0020
0.00038398
0.74949
CAL-51 INK-128
mTORC1/2
PI3K/mTOR
0.014971
 0.0529 0.5532 0.1010 0.9663
0.012822
0.99761
CAL-51 PF-4708671
p70S6K
PI3K/mTOR
37.1287
 0.7337 0.0491 0.0022 0.6083
225.4809
0.97513
CAL-51 Buparlisib
pan PI3K
PI3K/mTOR
0.9892
 -0.3883 0.3283 0.1186 1.5630
1.5215
0.99245
CAL-51 Pictilisib
pan PI3K
PI3K/mTOR
2.8949
 0.0266 0.1896 0.0461 0.7844
11.7472
0.98461
CAL-51 Ceritinib
ALK
RTK
0.47536
 -0.4763 0.4172 0.1229 1.1654
0.88025
0.99344
CAL-51 Neratinib
EGFR/HER2
RTK
2.2484
 0.2802 0.0910 0.0109 1.5163
4.6402
0.98601
CAL-51 Tivantinib
MET
RTK
0.58755
 -0.2821 0.3592 0.1039 1.5478
0.80088
0.99945
CAL-51 Cediranib
VEGFR/cKIT
RTK
3.0488
 -0.1033 0.1710 0.0517 1.0331
8.8303
0.9776
CAL-51 Cabozantinib
VEGFR2/MET
RTK
7.7705
 0.3063 0.0598 0.0166 1.8325
14.1514
0.98918
HCC1395 Abemaciclib
CDK4/6
Cell cycle
0.11228
 -0.5202 0.5623 0.0665 0.3941
1.8243
0.93379
HCC1395 Palbociclib
CDK4/6
Cell cycle
0.096119
 0.3481 0.2811 0.0192 1.5258
0.037341
0.98658
HCC1395 AZD7762
CHK1/2
Cell cycle
0.02128
 -0.6899 0.8845 0.2607 2.2723
0.028104
0.96763
HCC1395 Volasertib
PLK
Cell cycle
0.0032085
 -0.2962 0.7641 0.1714 2.7096
0.00378
0.99662