Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1328 Palbociclib
CDK4/6
Cell cycle
0.028878
 0.1110 0.4289 -0.0020 1.3039
0.020889
0.9674
PDX1328 AZD7762
CHK1/2
Cell cycle
0.035587
 -0.8228 0.8326 0.1855 1.2761
0.066257
0.96822
PDX1328 Volasertib
PLK
Cell cycle
0.0025124
 -0.5731 0.9694 0.2182 2.8453
0.0032751
0.99856
PDX1328 Dinaciclib
pan CDK
Cell cycle
0.011496
 -0.7107 0.7519 0.2292 3.5560
0.014708
0.9982
PDX1328 Cisplatin
Chemo
Chemotherapy
0.77968
 -0.4217 0.3154 0.0259 1.3251
1.2886
0.9879
PDX1328 Doxorubicin
Chemo
Chemotherapy
0.013267
 -0.7789 0.8023 0.1468 1.4934
0.021574
0.96338
PDX1328 Taxol
Chemo
Chemotherapy
0.002983
 -0.5332 0.9047 0.1888 3.1886
0.0036802
0.98401
PDX1328 Topotecan
Topo I
Chemotherapy
0.0059222
 -0.9128 1.0720 0.1509 0.4616
0.063175
0.94441
PDX1328 Etoposide
Topo II
Chemotherapy
0.80493
 -0.2805 0.3502 0.0172 1.4732
1.1571
0.98432
PDX1328 Dasatinib
BCR/ABL
MAPK/nRTK
0.035818
 -0.3368 0.6929 0.0612 0.7466
0.064434
0.94799
PDX1328 Trametinib
MEK
MAPK/nRTK
0.018054
 0.2490 0.3349 0.0167 1.3148
0.0076303
0.97089
PDX1328 Saracatinib
SRC
MAPK/nRTK
0.82476
 -0.0349 0.3256 0.0293 0.4526
9.3443
0.92264
PDX1328 ABT-737
Bcl2/XL
Misc
1.0279
 -0.8967 0.3548 0.1542 1.3255
2.3546
0.97784
PDX1328 Vorinostat
HDAC
Misc
0.41708
 -0.5588 0.4597 0.0854 1.1909
0.83181
0.99216
PDX1328 Luminespib
HSP90
Misc
0.0023764
 -0.4697 0.8697 0.1444 1.9222
0.0032941
0.9864
PDX1328 A-1210477
Mcl-1
Misc
29.0724
 0.7094 0.0609 0.0135 0.6451
128.4233
0.82503
PDX1328 Olaparib
PARP
Misc
Inf
 0.7634 0.0268 -0.0025 5.0000
1.7254
0.86133
PDX1328 Bleomycin
Radiation
Misc
4.0022
 0.3061 0.1994 0.0033 0.4524
45.3783
0.95786
PDX1328 Ipatasertib
AKT
PI3K/mTOR
4.7978
 0.3012 0.1323 0.0153 0.6377
26.7942
0.95509
PDX1328 Alpelisib
PI3Ka
PI3K/mTOR
0.31193
 -0.0050 0.3735 0.0319 0.8438
0.32361
0.95669
PDX1328 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0071031
 -0.2439 0.7440 0.0558 0.2650
0.08641
0.88652
PDX1328 TGX221
PI3Kb
PI3K/mTOR
22.8162
 0.7594 0.0116 0.0024 1.1153
60.9221
0.6986
PDX1328 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0028919
 -0.3715 0.7187 0.0739 0.8875
0.004646
0.98005
PDX1328 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.2825 0.6902 0.0347 0.0000
Inf
0.15246
PDX1328 INK-128
mTORC1/2
PI3K/mTOR
0.0042182
 -0.2955 0.8098 0.0628 1.2155
0.0054971
0.99054