Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MCF7 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0045641
 -0.1330 0.6027 0.1279 0.9398
0.0052657
0.98973
MCF7 Everolimus
mTOR1
PI3K/mTOR
0.0026919
 0.3865 0.5643 0.0341 0.2603
1.8439e-05
0.90097
MCF7 INK-128
mTORC1/2
PI3K/mTOR
0.00298
 -0.0450 0.7258 0.1347 1.1028
0.0028216
0.99089
MCF7 PF-4708671
p70S6K
PI3K/mTOR
14.8089
 0.5577 0.0586 0.0041 1.0532
5.6554
0.96631
MCF7 Buparlisib
pan PI3K
PI3K/mTOR
0.18746
 -0.2690 0.5035 0.1162 0.8936
0.34198
0.99189
MCF7 Pictilisib
pan PI3K
PI3K/mTOR
0.13012
 -0.1594 0.5057 0.1018 0.6167
0.24212
0.99423
MCF7 Ceritinib
ALK
RTK
0.34376
 -0.6157 0.4566 0.1487 0.9502
0.88109
0.9932
MCF7 Neratinib
EGFR/HER2
RTK
1.2629
 0.0582 0.1421 0.0220 1.0034
3.7746
0.97694
MCF7 Tivantinib
MET
RTK
0.1513
 -0.0512 0.4534 0.0984 1.7693
0.15446
0.99667
MCF7 Cediranib
VEGFR/cKIT
RTK
5.7041
 0.1149 0.0758 0.0191 1.5383
11.6508
0.98993
MCF7 Cabozantinib
VEGFR2/MET
RTK
4.8819
 -0.0993 0.1069 0.0302 1.8080
8.9638
0.99698
MDA-MB-231 Abemaciclib
CDK4/6
Cell cycle
0.046803
 -0.4875 0.6754 0.1393 0.3863
0.73058
0.97904
MDA-MB-231 Palbociclib
CDK4/6
Cell cycle
0.11065
 0.2066 0.3469 0.0101 0.7428
0.05699
0.98815
MDA-MB-231 AZD7762
CHK1/2
Cell cycle
0.15977
 -0.4632 0.5380 0.2422 0.9378
0.33846
0.98568
MDA-MB-231 Volasertib
PLK
Cell cycle
0.0043583
 -0.0186 0.5873 0.1359 3.6103
0.0044117
0.99795
MDA-MB-231 Dinaciclib
pan CDK
Cell cycle
0.010273
 -0.4203 0.6627 0.2555 2.6877
0.012709
0.99722
MDA-MB-231 Cisplatin
Chemo
Chemotherapy
2.415
 0.2721 0.1500 0.0084 1.6944
1.6486
0.99899
MDA-MB-231 Doxorubicin
Chemo
Chemotherapy
0.0050428
 -0.4864 0.8179 0.2092 1.0560
0.0077676
0.95921
MDA-MB-231 Taxol
Chemo
Chemotherapy
0.0023185
 -0.1204 0.7021 0.2576 1.1720
0.0026636
0.96432
MDA-MB-231 Topotecan
Topo I
Chemotherapy
0.029665
 -0.3241 0.7044 0.0793 0.6645
0.059258
0.94327
MDA-MB-231 Etoposide
Topo II
Chemotherapy
0.7036
 0.1203 0.2978 0.0095 1.5558
0.62323
0.99162
MDA-MB-231 Dasatinib
BCR/ABL
MAPK/nRTK
0.02942
 -0.1256 0.6475 0.1153 0.6812
0.03753
0.98521
MDA-MB-231 Trametinib
MEK
MAPK/nRTK
0.0026306
 -0.1785 0.7224 0.2816 1.1618
0.0033911
0.99829
MDA-MB-231 Saracatinib
SRC
MAPK/nRTK
2.3337
 0.2801 0.2687 0.0262 0.3311
64.4143
0.98467
MDA-MB-231 ABT-737
Bcl2/XL
Misc
3.031
 -0.1204 0.1616 0.0795 1.1097
8.1572
0.99586