Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MCF 10A Cediranib
VEGFR/cKIT
RTK
9.6397
 0.4781 0.0310 0.0012 3.3546
8.1
0.99825
MCF 10A Cabozantinib
VEGFR2/MET
RTK
25.9104
 0.8434 -0.0114 0.0040 4.9998
11.7694
0.81226
MCF7 Abemaciclib
CDK4/6
Cell cycle
0.023572
 -0.2684 0.7018 0.0913 0.3795
0.13917
0.95433
MCF7 Palbociclib
CDK4/6
Cell cycle
0.074952
 0.2542 0.3461 0.0139 1.0473
0.035667
0.99237
MCF7 AZD7762
CHK1/2
Cell cycle
0.04144
 -0.1856 0.5977 0.1318 0.8993
0.048851
0.95892
MCF7 Volasertib
PLK
Cell cycle
0.0028671
 -0.0338 0.6070 0.1245 4.2176
0.002824
0.99423
MCF7 Dinaciclib
pan CDK
Cell cycle
0.0083068
 -0.2493 0.6441 0.1256 3.5461
0.009348
0.9995
MCF7 Cisplatin
Chemo
Chemotherapy
9.3237
 0.4749 0.0631 0.0037 1.0987
15.5357
0.99433
MCF7 Doxorubicin
Chemo
Chemotherapy
0.016105
 -0.2856 0.6363 0.1012 0.9326
0.024539
0.97476
MCF7 Taxol
Chemo
Chemotherapy
0.0013771
 -0.1059 0.7722 0.1589 1.1560
0.0016261
0.94939
MCF7 Topotecan
Topo I
Chemotherapy
0.0060429
 -0.2711 0.8540 0.1220 1.1751
0.0071167
0.95657
MCF7 Etoposide
Topo II
Chemotherapy
0.13489
 -0.0441 0.4992 0.0261 1.3301
0.14783
0.99669
MCF7 Dasatinib
BCR/ABL
MAPK/nRTK
0.069398
 0.1574 0.4829 0.0400 1.6265
0.055227
0.99565
MCF7 Trametinib
MEK
MAPK/nRTK
Inf
 0.5581 0.2767 0.0114 1.2083
0.0027903
0.99413
MCF7 Saracatinib
SRC
MAPK/nRTK
0.57707
 0.2735 0.3223 0.0241 0.6671
0.25342
0.9907
MCF7 ABT-737
Bcl2/XL
Misc
22.5968
 0.7267 0.0146 0.0115 1.1080
29.1513
0.88699
MCF7 Vorinostat
HDAC
Misc
0.54198
 -0.1752 0.3494 0.0792 1.1946
0.72813
0.99735
MCF7 Luminespib
HSP90
Misc
0.0087135
 0.0015 0.5132 0.0620 2.7505
0.008705
0.99839
MCF7 A-1210477
Mcl-1
Misc
Inf
 0.8774 -0.0002 0.0007 1.8795
11.2338
0.74456
MCF7 Olaparib
PARP
Misc
10.3196
 0.5137 0.0554 0.0074 1.4485
14.0349
0.99551
MCF7 Bleomycin
Radiation
Misc
0.07723
 -0.0459 0.5554 0.0443 1.2323
0.083522
0.99888
MCF7 Ipatasertib
AKT
PI3K/mTOR
1.2964
 0.2497 0.2597 0.0350 0.6498
0.91468
0.99756
MCF7 Alpelisib
PI3Ka
PI3K/mTOR
0.58502
 0.0207 0.3259 0.0518 0.6552
0.82437
0.98733
MCF7 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0083619
 -0.2545 0.7677 0.1823 0.5107
0.014367
0.95432
MCF7 TGX221
PI3Kb
PI3K/mTOR
15.3151
 0.7893 -0.0068 0.0019 3.9246
12.6094
0.85557