Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Taxol | Chemo | Chemotherapy | 0.0026843 | -0.1256 | 0.7023 | 0.2576 | 1.8234 | 0.003018 | 0.9967 |
| MCF 10A | Topotecan | Topo I | Chemotherapy | 0.009871 | -0.2000 | 0.7653 | 0.1401 | 1.1478 | 0.01069 | 0.95965 |
| MCF 10A | Etoposide | Topo II | Chemotherapy | 0.28398 | -0.0699 | 0.4155 | 0.0691 | 1.3527 | 0.31593 | 0.99713 |
| MCF 10A | Dasatinib | BCR/ABL | MAPK/nRTK | 0.70911 | -0.0146 | 0.3385 | 0.0619 | 0.5303 | 2.8391 | 0.99012 |
| MCF 10A | Trametinib | MEK | MAPK/nRTK | 0.0033619 | 0.2252 | 0.5266 | -0.0015 | 1.2096 | 0.0021432 | 0.99763 |
| MCF 10A | Saracatinib | SRC | MAPK/nRTK | 4.8259 | 0.1485 | 0.1247 | 0.0066 | 1.0801 | 13.3454 | 0.99696 |
| MCF 10A | ABT-737 | Bcl2/XL | Misc | Inf | 0.8170 | 0.0104 | 0.0055 | 4.1268 | 4.3547 | 0.98669 |
| MCF 10A | Vorinostat | HDAC | Misc | 2.5293 | 0.0566 | 0.1675 | 0.0065 | 1.2709 | 3.1489 | 0.99982 |
| MCF 10A | Luminespib | HSP90 | Misc | 0.0076226 | -0.1717 | 0.6131 | 0.2622 | 3.1403 | 0.0083878 | 0.9999 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| MCF 10A | Olaparib | PARP | Misc | 59.3998 | 0.7945 | 0.0408 | -0.0007 | 0.6167 | 350.419 | 0.98306 |
| MCF 10A | Bleomycin | Radiation | Misc | 0.1774 | 0.0378 | 0.4490 | 0.0692 | 0.9923 | 0.1791 | 0.99758 |
| MCF 10A | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.6472 | 0.0600 | -0.0019 | 1.0758 | 4.7959 | 0.99868 |
| MCF 10A | Alpelisib | PI3Ka | PI3K/mTOR | 17.193 | 0.5787 | 0.1126 | -0.0029 | 0.4411 | 201.6709 | 0.99492 |
| MCF 10A | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.11877 | 0.0593 | 0.4844 | -0.0002 | 0.5049 | 0.12632 | 0.99608 |
| MCF 10A | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9505 | 0.0050 | 0.0003 | 0.8181 | 270.4333 | 0.86411 |
| MCF 10A | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.032009 | 0.1275 | 0.3368 | 0.0011 | 1.3839 | 0.02463 | 0.99809 |
| MCF 10A | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7889 | 0.1130 | 0.0000 | 0.4668 | 0.070049 | 0.96385 |
| MCF 10A | INK-128 | mTORC1/2 | PI3K/mTOR | 0.024199 | 0.1716 | 0.4673 | -0.0027 | 1.3149 | 0.017581 | 0.99992 |
| MCF 10A | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.7207 | 0.0475 | -0.0020 | 1.0315 | 4.381 | 0.99443 |
| MCF 10A | Buparlisib | pan PI3K | PI3K/mTOR | 1.465 | -0.1604 | 0.2493 | 0.0444 | 1.6479 | 1.8654 | 0.99356 |
| MCF 10A | Pictilisib | pan PI3K | PI3K/mTOR | 1.8745 | 0.1934 | 0.2623 | -0.0025 | 0.4160 | 26.2875 | 0.97592 |
| MCF 10A | Ceritinib | ALK | RTK | 2.9867 | -0.3186 | 0.1843 | 0.0521 | 1.3962 | 6.5603 | 0.98775 |
| MCF 10A | Neratinib | EGFR/HER2 | RTK | 0.10243 | 0.0959 | 0.3443 | 0.0215 | 1.1138 | 0.081751 | 0.99316 |
| MCF 10A | Tivantinib | MET | RTK | 0.18116 | -0.1502 | 0.4509 | 0.1498 | 2.3782 | 0.1918 | 0.99221 |