Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
Hs 578T A-1210477
Mcl-1
Misc
Inf
 0.9419 -0.0065 -0.0001 0.0000
Inf
0.41975
Hs 578T Olaparib
PARP
Misc
8.9082
 0.4435 0.0997 0.0101 1.0369
25.6993
0.93656
Hs 578T Bleomycin
Radiation
Misc
0.25197
 -0.1966 0.4462 0.2094 0.9580
0.37819
0.99872
Hs 578T Ipatasertib
AKT
PI3K/mTOR
4.5924
 0.4423 0.2458 0.0093 0.5006
0.34659
0.98155
Hs 578T Alpelisib
PI3Ka
PI3K/mTOR
11.8954
 0.5308 0.0905 0.0063 0.7199
54.7171
0.9693
Hs 578T Taselisib
PI3Ka, g, d
PI3K/mTOR
0.57529
 -0.0179 0.3736 0.0734 0.3919
8.8945
0.98886
Hs 578T TGX221
PI3Kb
PI3K/mTOR
34.4921
 0.7094 0.0668 0.0103 0.5623
243.351
0.9333
Hs 578T Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0070774
 -0.2174 0.5683 0.1373 0.7608
0.010409
0.98427
Hs 578T Everolimus
mTOR1
PI3K/mTOR
0.0056053
 0.4204 0.5273 0.0278 0.4084
2.87e-05
0.64462
Hs 578T INK-128
mTORC1/2
PI3K/mTOR
0.0090588
 -0.0708 0.6226 0.1010 1.2366
0.0087974
0.98428
Hs 578T PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.9143 0.0252 0.0005 2.0096
0.1778
0.76824
Hs 578T Buparlisib
pan PI3K
PI3K/mTOR
0.68631
 -0.3434 0.3760 0.1520 1.4596
1.0562
0.9918
Hs 578T Pictilisib
pan PI3K
PI3K/mTOR
1.1555
 0.0345 0.3109 0.0488 0.4397
14.0561
0.97858
Hs 578T Ceritinib
ALK
RTK
0.96543
 -0.4356 0.3052 0.1254 0.8330
3.6097
0.98175
Hs 578T Neratinib
EGFR/HER2
RTK
0.6444
 -0.1608 0.2025 0.0665 0.8744
2.2637
0.98743
Hs 578T Tivantinib
MET
RTK
0.33668
 -0.3204 0.4411 0.2071 2.0560
0.42597
0.99878
Hs 578T Cediranib
VEGFR/cKIT
RTK
0.55083
 -0.5723 0.3937 0.1358 0.6641
2.8803
0.96002
Hs 578T Cabozantinib
VEGFR2/MET
RTK
6.3728
 0.2155 0.1335 0.0452 1.3885
14.0588
0.89112
MCF 10A Abemaciclib
CDK4/6
Cell cycle
0.34027
 0.1513 0.3811 -0.0012 0.5714
0.28176
0.99756
MCF 10A Palbociclib
CDK4/6
Cell cycle
1.9503
 0.4544 0.1883 -0.0047 0.6492
0.23713
0.99244
MCF 10A AZD7762
CHK1/2
Cell cycle
1.8064
 -0.1800 0.2246 0.0802 0.8472
6.6065
0.99793
MCF 10A Volasertib
PLK
Cell cycle
0.022128
 -0.0887 0.4466 0.1711 3.5358
0.023168
0.99997
MCF 10A Dinaciclib
pan CDK
Cell cycle
0.016244
 -0.2300 0.5279 0.2344 5.0000
0.017523
0.99904
MCF 10A Cisplatin
Chemo
Chemotherapy
4.2937
 0.3794 0.0952 0.0149 2.1287
2.4561
0.99519
MCF 10A Doxorubicin
Chemo
Chemotherapy
0.010766
 -0.3242 0.6549 0.1054 1.4229
0.012388
0.96407