Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1806 INK-128
mTORC1/2
PI3K/mTOR
0.052338
 0.2620 0.3895 0.0353 0.9021
0.019916
0.9778
HCC1806 PF-4708671
p70S6K
PI3K/mTOR
Inf
 1.0500 -0.0207 -0.0033 0.0000
Inf
-0.67606
HCC1806 Buparlisib
pan PI3K
PI3K/mTOR
1.0455
 -0.2692 0.3051 0.1247 2.2933
1.2847
0.99486
HCC1806 Pictilisib
pan PI3K
PI3K/mTOR
5.8714
 0.1936 0.1178 0.0220 1.3031
13.6419
0.96395
HCC1806 Ceritinib
ALK
RTK
2.1149
 -0.4060 0.1766 0.0793 2.2387
2.8712
0.99364
HCC1806 Neratinib
EGFR/HER2
RTK
0.77903
 -0.0883 0.1927 0.0757 0.8116
3.0161
0.95894
HCC1806 Tivantinib
MET
RTK
0.27161
 -0.2185 0.4464 0.1810 3.1555
0.30267
0.99849
HCC1806 Cediranib
VEGFR/cKIT
RTK
4.9315
 0.0954 0.0645 0.0363 4.9998
4.7786
0.98723
HCC1806 Cabozantinib
VEGFR2/MET
RTK
11.367
 0.6905 -0.0025 0.0050 4.9955
13.3217
0.89668
Hs 578T Abemaciclib
CDK4/6
Cell cycle
0.077629
 -0.5825 0.6343 0.1966 0.4160
1.0889
0.95772
Hs 578T Palbociclib
CDK4/6
Cell cycle
0.15611
 0.3049 0.3195 0.0363 0.7223
0.037735
0.98196
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
Hs 578T Volasertib
PLK
Cell cycle
0.0025675
 -0.3123 0.8198 0.3337 3.0081
0.0029864
0.9987
Hs 578T Dinaciclib
pan CDK
Cell cycle
0.0089363
 -0.2388 0.6160 0.2121 4.9934
0.0096082
0.99916
Hs 578T Cisplatin
Chemo
Chemotherapy
1.5413
 0.0125 0.2347 0.0930 1.4392
1.6968
0.99339
Hs 578T Doxorubicin
Chemo
Chemotherapy
0.0041078
 -0.3466 0.8007 0.2450 1.2269
0.0052684
0.96807
Hs 578T Taxol
Chemo
Chemotherapy
0.0010154
 -0.3752 0.9535 0.4788 1.2811
0.0015458
0.95438
Hs 578T Topotecan
Topo I
Chemotherapy
0.0049855
 -0.4488 1.0175 0.4717 1.1814
0.0076404
0.9429
Hs 578T Etoposide
Topo II
Chemotherapy
0.41322
 -0.1361 0.3770 0.1666 2.0332
0.46109
0.99901
Hs 578T Dasatinib
BCR/ABL
MAPK/nRTK
0.038606
 -0.2442 0.7103 0.2679 0.9749
0.059157
0.98877
Hs 578T Trametinib
MEK
MAPK/nRTK
0.0063584
 0.1931 0.4907 0.0713 0.9022
0.0036513
0.99154
Hs 578T Saracatinib
SRC
MAPK/nRTK
4.0375
 0.1890 0.1594 0.0291 0.7110
18.9291
0.97543
Hs 578T ABT-737
Bcl2/XL
Misc
Inf
 0.7755 0.0260 0.0177 1.3421
4.2689
0.94189
Hs 578T Vorinostat
HDAC
Misc
0.90288
 -0.1689 0.2728 0.1049 2.2431
1.0225
0.99568
Hs 578T Luminespib
HSP90
Misc
0.0032976
 -0.1144 0.6699 0.2289 2.5765
0.0035402
0.99828