Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1328 PF-4708671
p70S6K
PI3K/mTOR
8.0727
 0.3935 0.0744 0.0073 1.0548
22.8735
0.93815
PDX1328 Buparlisib
pan PI3K
PI3K/mTOR
0.29807
 -0.5321 0.5596 0.0928 1.0980
0.65313
0.96818
PDX1328 Pictilisib
pan PI3K
PI3K/mTOR
0.2981
 -0.2326 0.4385 0.0405 0.5373
1.3322
0.97906
PDX1328 Ceritinib
ALK
RTK
0.25503
 -0.9426 0.5536 0.1190 0.8974
0.86749
0.9878
PDX1328 Neratinib
EGFR/HER2
RTK
0.13115
 -0.4202 0.4254 0.0466 0.5621
0.92594
0.97874
PDX1328 Tivantinib
MET
RTK
0.20199
 -0.5501 0.5704 0.1178 1.7021
0.31184
0.99706
PDX1328 Cediranib
VEGFR/cKIT
RTK
0.95412
 -0.8534 0.3764 0.0972 1.1127
2.5609
0.95134
PDX1328 Cabozantinib
VEGFR2/MET
RTK
1.8826
 -0.1622 0.2366 0.0206 0.7816
7.6768
0.95877
MDA-MB-134-VI Abemaciclib
CDK4/6
Cell cycle
Inf
 -0.9986 0.5722 0.0709 0.0000
Inf
0.086291
MDA-MB-134-VI Palbociclib
CDK4/6
Cell cycle
0.0092186
 0.1787 0.5339 -0.0169 1.7301
0.0071324
0.98727
MDA-MB-134-VI AZD7762
CHK1/2
Cell cycle
0.10625
 -0.6459 0.6552 0.1488 1.1125
0.22232
0.99438
MDA-MB-134-VI Volasertib
PLK
Cell cycle
0.0027209
 -0.6274 1.0260 0.2671 5.0000
0.0032225
0.99553
MDA-MB-134-VI Dinaciclib
pan CDK
Cell cycle
0.010529
 -0.8440 0.7452 0.1522 2.1701
0.015963
0.99365
MDA-MB-134-VI Cisplatin
Chemo
Chemotherapy
10.3229
 0.5019 0.0719 -0.0064 0.7594
36.1235
0.92643
MDA-MB-134-VI Doxorubicin
Chemo
Chemotherapy
0.0033105
 -0.9458 1.1481 0.2491 0.9132
0.010163
0.97259
MDA-MB-134-VI Taxol
Chemo
Chemotherapy
0.00012515
 -0.7183 1.3004 0.3511 0.5352
0.00075273
0.89205
MDA-MB-134-VI Topotecan
Topo I
Chemotherapy
0.0099907
 -0.8909 1.0405 0.1644 0.5440
0.071904
0.95834
MDA-MB-134-VI Etoposide
Topo II
Chemotherapy
0.086844
 -0.5248 0.6635 0.0687 0.6849
0.28885
0.9792
MDA-MB-134-VI Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.8878 -0.0289 0.0187 0.0000
Inf
0.37857
MDA-MB-134-VI Trametinib
MEK
MAPK/nRTK
0.0020578
 -0.2707 0.7601 0.0782 1.0824
0.0028809
0.99008
MDA-MB-134-VI Saracatinib
SRC
MAPK/nRTK
Inf
 1.0500 -0.0500 0.0181 0.0000
Inf
-Inf
MDA-MB-134-VI ABT-737
Bcl2/XL
Misc
1.7727
 -0.8735 0.2629 0.1112 1.9770
3.09
0.99496
MDA-MB-134-VI Vorinostat
HDAC
Misc
2.4577
 -0.5014 0.1748 0.0365 5.0000
2.8258
0.99386
MDA-MB-134-VI Luminespib
HSP90
Misc
0.0047553
 -0.7660 0.9424 0.2076 3.5318
0.006139
0.99851
MDA-MB-134-VI A-1210477
Mcl-1
Misc
Inf
 1.0500 -0.0366 -0.0033 0.0000
Inf
-3.0589