Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Abemaciclib | CDK4/6 | Cell cycle | 0.59453 | -0.4440 | 0.3921 | 0.1035 | 0.6190 | 3.5069 | 0.96621 |
| HCC1806 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.6924 | 0.1460 | 0.0085 | 1.6543 | 0.024125 | 0.93749 |
| HCC1806 | AZD7762 | CHK1/2 | Cell cycle | 0.016629 | -0.4822 | 0.8897 | 0.3907 | 1.6771 | 0.023183 | 0.99277 |
| HCC1806 | Volasertib | PLK | Cell cycle | 0.0027998 | -0.1323 | 0.7262 | 0.2950 | 5.0000 | 0.0029495 | 0.99776 |
| HCC1806 | Dinaciclib | pan CDK | Cell cycle | 0.013395 | -0.4585 | 0.6439 | 0.3114 | 3.4710 | 0.016174 | 0.99891 |
| HCC1806 | Cisplatin | Chemo | Chemotherapy | 0.82764 | -0.3648 | 0.3231 | 0.1009 | 1.1777 | 1.5296 | 0.98889 |
| HCC1806 | Doxorubicin | Chemo | Chemotherapy | 0.015898 | -0.3241 | 0.6281 | 0.1971 | 1.0948 | 0.021206 | 0.97525 |
| HCC1806 | Taxol | Chemo | Chemotherapy | 0.0014225 | -0.2113 | 0.8398 | 0.3493 | 2.1569 | 0.0016621 | 0.96243 |
| HCC1806 | Topotecan | Topo I | Chemotherapy | 0.0052709 | -0.5458 | 1.0747 | 0.3515 | 1.0834 | 0.0094879 | 0.95633 |
| HCC1806 | Etoposide | Topo II | Chemotherapy | 0.096233 | -0.5629 | 0.6490 | 0.2019 | 0.9767 | 0.2057 | 0.99535 |
| HCC1806 | Dasatinib | BCR/ABL | MAPK/nRTK | 0.053677 | -0.0992 | 0.6297 | 0.1625 | 1.4311 | 0.062326 | 0.98998 |
| HCC1806 | Trametinib | MEK | MAPK/nRTK | Inf | 0.7036 | 0.1086 | 0.0280 | 4.8006 | 0.007609 | 0.89189 |
| HCC1806 | Saracatinib | SRC | MAPK/nRTK | 1.73 | 0.2213 | 0.2336 | 0.0480 | 0.6559 | 1.8399 | 0.97728 |
| HCC1806 | ABT-737 | Bcl2/XL | Misc | 12.0843 | 0.7293 | -0.0285 | 0.0138 | 5.0000 | 12.4641 | 0.7932 |
| HCC1806 | Vorinostat | HDAC | Misc | 1.1276 | 0.0178 | 0.2397 | 0.0491 | 1.3263 | 1.2167 | 0.99564 |
| HCC1806 | Luminespib | HSP90 | Misc | 0.010903 | -0.1751 | 0.5413 | 0.2054 | 2.8582 | 0.012009 | 0.99662 |
| HCC1806 | A-1210477 | Mcl-1 | Misc | Inf | 0.9047 | -0.0078 | 0.0015 | 4.2962 | 12.7646 | 0.58471 |
| HCC1806 | Olaparib | PARP | Misc | 10.3367 | 0.4886 | 0.0953 | 0.0224 | 0.7744 | 42.7088 | 0.92848 |
| HCC1806 | Bleomycin | Radiation | Misc | 8.9432 | 0.4813 | 0.1206 | 0.0253 | 0.8891 | 1.9034 | 0.96208 |
| HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
| HCC1806 | Alpelisib | PI3Ka | PI3K/mTOR | 24.5643 | 0.7260 | 0.0386 | 0.0042 | 0.9323 | 42.9713 | 0.94371 |
| HCC1806 | Taselisib | PI3Ka, g, d | PI3K/mTOR | 1.5787 | -0.0297 | 0.2583 | 0.0605 | 0.5749 | 10.6705 | 0.98019 |
| HCC1806 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9819 | -0.0154 | 0.0035 | 0.0000 | Inf | -0.19348 |
| HCC1806 | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.03581 | -0.1402 | 0.3877 | 0.1005 | 0.9893 | 0.048229 | 0.99141 |
| HCC1806 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.8168 | 0.1972 | 0.0004 | 0.0000 | Inf | -2.9998e-08 |