Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9469.026 | uM | inf | inf | 0.8380 | 0.8380 | 0.0000 | 0.0264 | 0.4874 | 1.2092 | |
| HCC70 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 9501.026 | uM | 7.09240 | 7.60970 | 0.4779 | -0.2089 | 4.9603 | 0.0540 | 0.7273 | 0.7616 | |
| HCC1419 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9278.026 | uM | 0.34018 | 65.36710 | 0.0640 | -1.0000 | 0.2089 | 0.3320 | 0.7476 | 0.3395 | |
| HCC1954 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 9386.026 | uM | inf | inf | 0.7531 | 0.7531 | 0.0000 | 0.0956 | 0.4287 | 1.5583 | |
| HCC38 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 10268.122 | uM | 3.49450 | 1.70630 | 0.4865 | 0.4861 | 4.9935 | 0.0343 | 0.6574 | 0.6345 | |
| HCC1569 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 7447.102 | uM | inf | 0.00181 | 0.7277 | 0.8106 | 1.1886 | 0.1183 | 0.8186 | 1.6467 | |
| BT-483 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9186.026 | uM | 9.98070 | 8.38730 | 0.7741 | 0.2905 | 5.0000 | -0.0274 | 0.7463 | 0.5108 | |
| CAMA-1 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9210.026 | uM | inf | inf | 0.9536 | 0.9536 | 0.0000 | -0.0426 | -1.3374 | 0.9102 | |
| HCC1419 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 10019.124 | uM | 8.22850 | 7.66340 | 0.6382 | 0.1473 | 4.9063 | 0.0323 | 0.6853 | 0.5356 | |
| HCC1395 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9254.124 | uM | inf | inf | 0.8784 | 0.8784 | 0.0000 | -0.0335 | 0.3867 | 0.8067 | |
| HCC1806 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 9376.026 | uM | inf | inf | 0.9395 | 0.9395 | 0.0000 | -0.0232 | 0.0979 | 1.6827 | |
| HCC1428 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 7441.102 | uM | inf | inf | 0.9313 | 0.9313 | 0.0000 | -0.0087 | 0.3093 | 0.9144 | |
| BT-474 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9163.026 | uM | 0.00135 | 0.0020 | -0.6688 | -0.4240 | 1.5559 | 0.8993 | 0.9648 | 0.3738 | |
| HCC1569 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 9347.026 | uM | inf | inf | 0.7097 | 0.7097 | 0.0000 | 0.0656 | 0.4960 | 1.2965 | |
| 184A1 | NM | Basal | Trastuzumab | HER2 | ErbB | 9047.026 | uM | inf | inf | 0.2837 | 0.2837 | 0.0000 | 0.2170 | 0.0804 | 0.5972 | |
| BT-20 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 5903.102 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0171 | -0.1575 | 1.2557 | |
| BT-549 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 10261.026 | uM | inf | 7.81790 | 0.8340 | 0.5838 | 4.9972 | -0.0048 | 0.8731 | 2.4866 | |
| 184B5 | NM | Basal | Trastuzumab | HER2 | ErbB | 9095.026 | uM | inf | 6.71320 | 0.7144 | 0.5130 | 4.9565 | -0.0290 | 0.80 | 1.0168 | |
| HCC1143 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 9233.124 | uM | inf | inf | 0.8121 | 0.8121 | 0.0000 | 0.0617 | 0.3873 | 0.9990 | |
| HBL-100 | Unknown | Unknown | Trastuzumab | HER2 | ErbB | 7429.102 | uM | inf | 1.42040 | 0.9243 | 0.9093 | 0.9467 | 0.0072 | 0.8090 | 2.4347 | |
| HCC1395 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9258.026 | uM | inf | inf | 0.5784 | 0.5784 | 0.0000 | 0.1398 | 0.2126 | 0.5632 | |
| AU565 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9146.122 | uM | inf | 0.00184 | 0.5003 | 0.6442 | 5.0000 | 0.2137 | 0.8848 | 1.3408 | |
| BT-474 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9158.123 | uM | 0.01277 | 0.00885 | -0.0100 | 0.0993 | 0.6043 | 0.4533 | 0.9046 | 0.8769 | |
| MCF 10A | NM | Basal B | Trastuzumab | HER2 | ErbB | 9551.026 | uM | inf | inf | 0.9124 | 0.9124 | 0.0000 | -0.0111 | 0.4645 | 2.6508 | |
| LY2 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10264.026 | uM | inf | inf | 0.8544 | 0.8544 | 0.0000 | 0.0234 | 0.5438 | 1.5047 |