Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 10002.001 | uM | 6.06620 | 9.11620 | -0.9717 | -1.0000 | 2.6972 | 0.2605 | 0.9735 | 0.5372 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 10002.001 | uM | 0.64737 | 2.67080 | -0.5505 | -0.8031 | 0.6759 | 0.3916 | 0.9922 | 0.5372 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 10002.001 | uM | 8.47170 | 11.6240 | -0.9507 | -1.0000 | 3.4729 | 0.2407 | 0.9439 | 0.5372 | |
| 184A1 | NM | Basal | Taxol | TUBB | TUBB | 10002.002 | uM | 0.03993 | 0.01744 | 0.3992 | 0.4147 | 2.1347 | 0.3380 | 0.9787 | 0.9502 | |
| 184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 10002.002 | uM | inf | 0.00813 | 0.5141 | 0.5151 | 1.4431 | 0.2780 | 0.7979 | 0.9502 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 10002.012 | uM | 0.00246 | 0.00373 | -0.3319 | -0.3425 | 1.2572 | 0.8816 | 0.9950 | 0.5807 | |
| 184A1 | NM | Basal | Geldanamycin | HSP90 | HSP90 | 10002.012 | uM | 0.00232 | 0.00278 | -0.4963 | -0.4694 | 3.6140 | 1.2014 | 0.9946 | 0.5807 | |
| 184A1 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 10002.021 | uM | 2.61470 | 4.77760 | -0.9719 | -0.9559 | 1.7730 | 0.6305 | 0.9959 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 10002.021 | uM | 13.72870 | 19.0030 | -0.8276 | -0.7818 | 2.8956 | 0.6151 | 0.9925 | 0.7195 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10002.021 | uM | 1.98010 | 5.92780 | -0.9908 | -1.0000 | 1.0019 | 0.7527 | 0.9764 | 0.7195 | |
| 184A1 | NM | Basal | CPT-11 | TOP1 | TOP | 10002.034 | uM | 3.43020 | 4.22870 | -0.9255 | -0.9233 | 4.9992 | 0.4247 | 0.9962 | 0.6736 | |
| 184A1 | NM | Basal | Doxorubicin | TOP2 | TOP | 10002.034 | uM | 0.10668 | 0.20741 | -1.0000 | -0.9682 | 1.6201 | 0.9516 | 0.9936 | 0.6736 | |
| 184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 10002.034 | uM | 242.78660 | 399.08510 | -0.9907 | -1.0000 | 2.2105 | 0.6269 | 0.7996 | 0.6736 | ||
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10019.001 | uM | 1.07080 | 10.8130 | -0.4023 | -1.0000 | 0.4751 | 0.3243 | 0.8739 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10019.001 | uM | 7.27140 | 9.02660 | -0.9678 | -0.9707 | 4.9898 | 0.1937 | 0.9732 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10019.001 | uM | 6.32170 | 7.28910 | -0.5182 | -0.5189 | 4.9999 | 0.2040 | 0.9453 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10019.002 | uM | 0.47272 | 1.90670 | 0.0482 | -0.3033 | 0.3399 | 0.3675 | 0.7925 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10019.002 | uM | 0.03102 | 0.02212 | 0.3860 | 0.4078 | 4.9999 | 0.2530 | 0.9570 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 10019.037 | uM | 0.08594 | 0.10557 | -0.9986 | -0.8989 | 5.0000 | 1.0136 | 0.9958 | 0.4232 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10019.049 | uM | 0.04194 | 0.05941 | -0.9260 | -0.8573 | 2.8690 | 1.0457 | 0.9977 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10019.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0250 | -0.1954 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 10019.049 | uM | 2.99220 | 5.48580 | -0.9159 | -0.9898 | 1.8011 | 0.2683 | 0.9944 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10019.12 | uM | 43.09170 | 78.77850 | -0.9916 | -0.9762 | 1.7945 | 0.4068 | 0.9964 | 0.4898 | |
| HCC1419 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10019.12 | uM | 9.94530 | 28.0190 | -0.9970 | -1.0000 | 1.0607 | 0.5208 | 0.9649 | 0.4898 | |
| HCC1419 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10019.12 | uM | 18.64930 | 0.19440 | 0.4546 | 0.4882 | 0.8207 | 0.2321 | 0.6442 | 0.4898 |