Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Torkinib | 15346.211 | uM | 0.00002 | 0.00009 | -0.6847 | -0.6526 | 0.5569 | 1.5120 | 0.9820 | 0.6395 | |||
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9402.001 | uM | 0.00002 | 0.09136 | -0.5692 | -1.0000 | 0.1320 | 0.9532 | 0.7655 | 0.6567 | |
| MDA-MB-468 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7906.018 | uM | 0.00003 | 0.00009 | -0.9241 | -0.7076 | 0.8524 | 1.6148 | 0.7919 | 0.9087 | |
| EFM-19 | HR+ | Luminal | Torkinib | 15296.211 | uM | 0.00003 | 0.00091 | -0.4760 | -0.5739 | 0.2205 | 1.1055 | 0.9560 | 1.4068 | |||
| UACC-812 | HER2amp | Luminal | Torkinib | 15404.211 | uM | 0.00005 | 0.00056 | -0.8141 | -0.8007 | 0.3960 | 1.4387 | 0.9967 | 0.5754 | |||
| SUM52PE | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7540.068 | uM | 0.00006 | 0.02391 | -0.9666 | -1.0000 | 0.1851 | 1.1952 | 0.7788 | 0.9679 | |
| MCF7 | HR+ | Luminal | Torkinib | 15394.211 | uM | 0.00006 | 0.00015 | -0.2414 | -0.2040 | 0.3606 | 1.0163 | 0.9695 | 1.8299 | |||
| BT-20 | TNBC | Basal A | Torkinib | 15385.211 | uM | 0.00007 | 0.00943 | -0.7410 | -0.9904 | 0.2213 | 1.1960 | 0.990 | 0.7321 | |||
| MCF7 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7493.095 | uM | 0.00008 | 0.02291 | -0.9964 | -1.0000 | 0.1944 | 1.0719 | 0.7483 | 1.0092 | |
| SUM52PE | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10695.144 | uM | 0.00009 | 0.11643 | -0.9723 | -1.0000 | 0.1538 | 1.0263 | 0.6812 | 1.2333 | |
| SUM44PE | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7538.068 | uM | 0.00014 | 0.00030 | -0.2424 | -0.1582 | 0.3753 | 1.0105 | 0.7167 | 0.8203 | |
| HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7837.042 | uM | 0.00015 | 0.00026 | -0.8248 | -0.4139 | 1.1755 | 1.2659 | 0.6601 | 1.6916 | |
| MDA-MB-134-VI | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7494.094 | uM | 0.00016 | 0.02576 | -0.9888 | -1.0000 | 0.2157 | 1.2454 | 0.6904 | 0.9794 | |
| HCC2185 | TNBC | Luminal | Torkinib | 15306.211 | uM | 0.00017 | 0.00130 | -0.8220 | -0.8191 | 0.4777 | 1.4061 | 0.9962 | 0.4935 | |||
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7463.068 | uM | 0.00019 | 0.00017 | -0.0655 | 0.0169 | 0.3266 | 0.8520 | 0.8086 | 0.5887 | |
| T47DKBLUC | Unknown | Unknown | Torkinib | 15360.211 | uM | 0.00023 | 0.00037 | -0.1763 | -0.1097 | 0.4213 | 0.9138 | 0.9795 | 0.8772 | |||
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7813.018 | uM | 0.00024 | 0.00082 | -0.9987 | -0.8558 | 0.8040 | 1.5321 | 0.9392 | 0.8420 | |
| MDA-MB-134-VI | HR+ | Luminal | Torkinib | 15355.211 | uM | 0.00026 | 0.00531 | -0.8198 | -0.8282 | 0.3225 | 1.2019 | 0.9869 | 1.0584 | |||
| HCC38 | TNBC | Basal B | Torkinib | 15351.211 | uM | 0.00026 | 0.00145 | -0.9254 | -0.8879 | 0.5960 | 1.4733 | 0.9779 | 1.0866 | |||
| ZR75B | HR+ | Luminal | Torkinib | 15405.211 | uM | 0.00030 | 0.00154 | -0.3164 | -0.3506 | 0.3246 | 0.9816 | 0.9922 | 1.5333 | |||
| SUM52PE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7541.095 | uM | 0.00031 | 0.00056 | -0.9787 | -0.3061 | 0.7899 | 1.0595 | 0.6623 | 1.4542 | |
| MDA-MB-361 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10643.144 | uM | 0.00033 | 0.26653 | -0.9989 | -1.0000 | 0.1640 | 0.9661 | 0.6596 | 0.7178 | |
| MDA-MB-436 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7900.018 | uM | 0.00034 | 0.00766 | -0.9981 | -0.8167 | 0.3116 | 1.1293 | 0.8603 | 0.8304 | |
| HCC1187 | TNBC | Basal A | Torkinib | 15300.211 | uM | 0.00035 | 0.03423 | -0.7443 | -1.0000 | 0.2401 | 1.0888 | 0.9649 | 0.8961 | |||
| BT-483 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10696.144 | uM | 0.00036 | 0.00456 | -0.9999 | -0.6629 | 0.3339 | 1.1855 | 0.8042 | 0.4505 |