LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | R406 | 10.0 | uM | LJP6 | 72 | hr | 513 | 3361 | 10401 | 0.3232 | 0.2880 |
| MCF 10A | Pictilisib | 10.0 | uM | LJP6 | 72 | hr | 513 | 704 | 10401 | 0.0677 | 0.0193 |
| MCF 10A | Gefitinib | 10.0 | uM | LJP6 | 72 | hr | 513 | 824 | 10401 | 0.0793 | 0.0315 |
| MCF 10A | Geldanamycin | 10.0 | uM | LJP5 | 72 | hr | 513 | 307 | 10401 | 0.0296 | -0.0208 |
| MCF 10A | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 513 | 262 | 10401 | 0.0252 | -0.0254 |
| MCF 10A | GSK1059615 | 10.0 | uM | LJP5 | 72 | hr | 513 | 283 | 10401 | 0.0272 | -0.0233 |
| MCF 10A | GSK1059615 | 10.0 | uM | LJP6 | 72 | hr | 513 | 317 | 10401 | 0.0305 | -0.0199 |
| MCF 10A | GSK1904529A | 10.0 | uM | LJP6 | 72 | hr | 513 | 2684 | 10401 | 0.2581 | 0.2196 |
| MCF 10A | Omipalisib | 10.0 | uM | LJP6 | 72 | hr | 513 | 397 | 10401 | 0.0382 | -0.0117 |
| MCF 10A | GSK 690693 | 10.0 | uM | LJP5 | 72 | hr | 513 | 7361 | 10401 | 0.7077 | 0.6926 |
| MCF 10A | GW843682X | 10.0 | uM | LJP6 | 72 | hr | 513 | 701 | 10401 | 0.0674 | 0.0190 |
| MCF 10A | HG-5-113-01 | 10.0 | uM | LJP5 | 72 | hr | 513 | 559 | 10401 | 0.0537 | 0.0046 |
| MCF 10A | HG-5-88-01 | 10.0 | uM | LJP6 | 72 | hr | 513 | 1800 | 10401 | 0.1731 | 0.1302 |
| MCF 10A | Imatinib | 10.0 | uM | LJP6 | 72 | hr | 513 | 11029 | 10401 | 1.0604 | 1.0635 |
| MCF 10A | JNK-9L | 10.0 | uM | LJP6 | 72 | hr | 513 | 515 | 10401 | 0.0495 | 0.0002 |
| MCF 10A | JW-7-24-1 | 10.0 | uM | LJP6 | 72 | hr | 513 | 604 | 10401 | 0.0581 | 0.0092 |
| MCF 10A | Lapatinib | 10.0 | uM | LJP6 | 72 | hr | 513 | 770 | 10401 | 0.0741 | 0.0260 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 513 | 132 | 10401 | 0.0127 | -0.0385 |
| MCF 10A | Linifanib | 10.0 | uM | LJP6 | 72 | hr | 513 | 2516 | 10401 | 0.2420 | 0.2026 |
| MCF 10A | Linsitinib | 10.0 | uM | LJP5 | 72 | hr | 513 | 2013 | 10401 | 0.1936 | 0.1517 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 513 | 403 | 10401 | 0.0387 | -0.0112 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 513 | 464 | 10401 | 0.0446 | -0.0050 |
| MCF 10A | MK2206 | 10.0 | uM | LJP6 | 72 | hr | 513 | 2063 | 10401 | 0.1983 | 0.1567 |
| MCF 10A | Neratinib | 10.0 | uM | LJP5 | 72 | hr | 513 | 664 | 10401 | 0.0639 | 0.0153 |
| MCF 10A | Nilotinib | 10.0 | uM | LJP5 | 72 | hr | 513 | 3764 | 10401 | 0.3619 | 0.3288 |