Linsitinib - Small Molecule (ID:10135-101)
HMS LINCS ID: | 10135-101 |
Name: | Linsitinib |
Alternative Names: | OSI 906 |
LINCS ID: | LSM-1135 |
PubChem CID: | 11640390 |
ChEBI ID: | |
ChEMBL ID: | 1091644 |
Molecular Mass: | 421.19 |
InChi: | InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28) |
InChi Key: | PKCDDUHJAFVJJB-UHFFFAOYSA-N |
SMILES: | CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
IGF1R, INSR | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, AIM1, AURKB, BLK, ERBB4, FLT1, FLT4, FYN, LCK, LYN, MAP4K2, MAP4K5, RET, ROCK1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AKT1, AKT2, ALK, AURKA, BTK, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC42BPA, CDC7, CDK1, CDK2, CHEK1, CHEK2, CLK2, CSF1R, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK4, EGFR, EPHA2, ERBB2, FER, FES, FGFR1, FGFR3, FLG, FLT3, FRK, GSK3A, GSK3B, HIPK2, HIPK4, IRAK1, ITK, JAK2, JAK3, KDR, KIT, MAPK1, MAPK12, MAPK13, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MET, NEK2, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PDK1, PDPK1, PHKG2, PIM2, PIM3, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCZ, PRKG1, PRKG2, PRKX, ROCK2, ROS1, RPS6KA3, RPS6KA5, RPS6KB1, SRC, SRMS, SRPK1, STK17A, STK3, SYK, TSSK1B, TSSK2, TYK2, TYRO3 |
10 (confirmed non-binding) |
Batch Information for HMSL10135-101-1:
HMS LINCS Batch ID: | 10135-101-1 |
Provider: | Haoyuan chemexpress |
Provider Batch ID: | HM-101_17-20110627 |
Salt: | 101 |
Molecular Formula: | C26H23N5O |
Molecular Weight: | 421.49 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10135-101-1:
Date | HMS QC Outcome | Comment | Files |
---|---|---|---|
04/13/2015 | PASS | HMSL10135-101-1_LCMS.pdf | |
11/14/2011 | PASS | None |
(Kd <100 nM)