Linifanib - Small Molecule (ID:10182-101)
HMS LINCS ID: | 10182-101 |
Name: | Linifanib |
Alternative Names: | ABT-869; AL-39324 |
LINCS ID: | LSM-1183 |
PubChem CID: | 11485656 |
ChEBI ID: | |
ChEMBL ID: | |
Molecular Mass: | 375.15 |
InChi: | InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) |
InChi Key: | MPVGZUGXCQEXTM-UHFFFAOYSA-N |
SMILES: | CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
AURKC, CDK13, CDK19, CDK8, CSF1R, DDR1, EPHB6, FLT1, FLT3, FLT4, HIPK4, KDR, KIT, MUSK, PDGFRA, PDGFRB | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AIM1, AURKB, AXL, BMPR1B, EPHA6, EPHA7, EPHB1, FRK, LTK, MAP3K19, MAP4K1, MAP4K5, MAPK11, MAPK9, MERTK, MKNK2, NTRK3, RET, ROCK2, SLK, STK10, STK32A, STK32B, TAOK1, TAOK3, TEK, TIE1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ABL1, ALK, AURKA, BMPR2, C8orf44-SGK3, CDC42BPG, CDC7, CDK1, CDK11A, CDK11B, CDK16, CDK7, CDK9, CHUK, CLK1, CLK4, CSNK1A1, DDR2, DYRK1A, DYRK3, DYRK4, EEF2K, EGFR, EPHA3, EPHA5, EPHB2, EPHB3, EPHB4, ERBB4, GAK, GRK5, HIPK2, HIPK3, IKBKB, INSRR, IRAK1, IRAK4, LATS1, LATS2, LIMK2, MAP2K5, MAP4K2, MAP4K3, MAPK10, MAPK12, MAPK13, MAPK15, MATK, MET, MINK1, MKNK1, MST1, MST1R, MYLK2, MYO3B, NEK4, NTRK1, NTRK2, PBK, PLK3, PLK4, PRKACA, PRKCG, PRKCI, PRKCZ, RIPK1, ROCK1, RPS6KA4, RPS6KA5, RPS6KB1, SGK2, SGK3, STK26, STK3, STK33, STK4, TBK1, TKT, TNIK, TSSK2 |
10 (confirmed non-binding) |
Batch Information for HMSL10182-101-1:
HMS LINCS Batch ID: | 10182-101-1 |
Provider: | Haoyuan chemexpress |
Provider Batch ID: | HY-50751_1-20110708 |
Salt: | 101 |
Molecular Formula: | C21H18FN5O |
Molecular Weight: | 375.4 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10182-101-1:
Date | HMS QC Outcome | Comment | Files |
---|---|---|---|
04/13/2015 | PASS | HMSL10182-101-1_LCMS.pdf | |
11/14/2011 | PASS | None |
(Kd <100 nM)