GSK 690693 - Small Molecule (ID:10128-101)

HMS LINCS ID: 10128-101
Name: GSK 690693
Alternative Names:
LINCS ID: LSM-1128
PubChem CID: 16048642
ChEBI ID:
ChEMBL ID:
Molecular Mass: 425.22
InChi: InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)
InChi Key: KGPGFQWBCSZGEL-UHFFFAOYSA-N
SMILES: CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AKT1, AKT2, AKT3, BUB1B-PAK6, MAP3K19, NUAK2, PAK4, PAK5, PAK6, PKN1, pknB, Prkaa2, PRKACA, PRKACB, PRKCB, PRKCD, PRKCE, PRKCH, PRKCQ, PRKG2, PRKX, RPS6KA4
2
(equivalent to 100 nM ≤ Kd < 1µM)
CAMK4, CIT, CLK2, DAPK3, DCLK3, GRK1, GRK7, GSK3B, HIPK1, HIPK2, HIPK3, LATS2, MAP3K2, MAP3K3, MARK2, MELK, NUAK1, PAK1, PAK2, PIM1, PIM2, PIM3, PRKCI, PRKD3, PRKG1, ROCK1, ROCK2, RPS6KA5, TAOK1
3
(equivalent to 1µM ≤ Kd < 10 µM)
C8orf44-SGK3, CAMK1D, CHEK2, DAPK1, DCLK1, EIF2AK2, GSK3A, KIT, NLK, PDGFRB, PIP5K1C, PKD1, PKN2, PRKD1, RET, RPS6KA1, SGK3, SIK2, STK26, STK36, TAOK2, TAOK3, ULK1, ULK2
10
(confirmed non-binding)
(Click to show)

Batch Information for HMSL10128-101-1:

HMS LINCS Batch ID: 10128-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HM-092A_13-20110315
Salt: 101
Molecular Formula: C21H27N7O3
Molecular Weight: 425.48
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10128-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10128-101-1_LCMS.pdf
11/14/2011 PASS None