Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Ispinesib | BT-474 | -4.4776 | 0.9278 | -6.3866 | -6.3865 | -7.2715 | 0.6841 | 0.0000 | 0.0483 | 5.9228 |
| Ispinesib | BT-483 | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 6.6172 |
| Ispinesib | BT-549 | -4.4776 | 0.9010 | -7.3781 | -7.3129 | -7.3485 | 3.9965 | 0.2244 | 0.2244 | 5.7503 |
| Ispinesib | CAMA-1 | -4.4776 | 0.9764 | -7.5631 | -7.5265 | -7.6633 | 3.6505 | 0.1281 | 0.1281 | 4.6158 |
| Ispinesib | HCC1143 | -4.4776 | 0.9009 | -7.3106 | -7.2277 | -7.3096 | 3.9990 | 0.2676 | 0.2676 | 5.7668 |
| Ispinesib | HCC1395 | -4.4776 | 0.9518 | -7.5201 | -7.4459 | -7.7305 | 2.6980 | 0.1555 | 0.1555 | 4.9063 |
| Ispinesib | HCC1419 | -4.4776 | 0.9346 | -4.9434 | -4.9434 | -5.2287 | 3.9345 | 0.0000 | 0.0147 | 7.8012 |
| Ispinesib | HCC1428 | -4.4776 | 0.8473 | -5.2032 | -5.2032 | -5.9047 | 1.7565 | 0.0000 | 0.1257 | 7.1280 |
| Ispinesib | HCC1569 | -4.4776 | 0.8404 | -6.1916 | -6.1916 | -6.3647 | 0.4363 | 0.0000 | 0.1514 | 6.1333 |
| Ispinesib | HCC1806 | -4.4776 | 0.9677 | -7.6056 | -7.5647 | -7.6317 | 3.4310 | 0.1391 | 0.1391 | 4.7889 |
| Ispinesib | HCC1937 | -4.4776 | 0.9181 | -6.0986 | -6.0986 | -6.5202 | 0.6106 | 0.0000 | 0.0946 | 6.2071 |
| Ispinesib | HCC1954 | -4.4776 | 0.9862 | -7.6346 | -7.6273 | -7.6930 | 3.8165 | 0.0307 | 0.0307 | 4.0712 |
| Ispinesib | HCC202 | -4.4776 | 0.9414 | -7.7126 | -7.6062 | -8.1286 | 1.4930 | 0.1532 | 0.1532 | 4.6928 |
| Ispinesib | HCC38 | -4.4776 | 0.9431 | -7.3721 | -7.3108 | -7.4034 | 3.6725 | 0.2012 | 0.2012 | 5.2042 |
| Ispinesib | HCC70 | -4.4776 | 0.9590 | -7.3376 | -7.2934 | -7.4217 | 4.0000 | 0.1686 | 0.1686 | 5.1351 |
| Ispinesib | Hs 578T | -4.4776 | 0.7565 | -6.3306 | -6.3188 | -6.5654 | 0.5607 | 0.0074 | 0.0976 | 6.0851 |
| Ispinesib | MB 157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Ispinesib | MDA-MB-134-VI | -4.4776 | 0.9215 | -7.0676 | -6.8811 | -7.3984 | 1.2190 | 0.2037 | 0.2043 | 5.5852 |
| Ispinesib | MDA-MB-157 | -4.4776 | 0.9458 | -7.4786 | -7.4012 | -7.5715 | 3.0320 | 0.1934 | 0.1934 | 5.1245 |
| Ispinesib | MDA-MB-175-VII | -4.4776 | 0.8011 | -5.2565 | -5.2564 | -6.0577 | 0.7518 | 0.0000 | 0.2062 | 6.8961 |
| Ispinesib | MDA-MB-361 | -4.4776 | 0.9074 | -7.4466 | -7.3308 | -7.4990 | 3.9980 | 0.2389 | 0.2395 | 5.7432 |
| Ispinesib | MDA-MB-436 | -4.4776 | 0.8971 | -7.5336 | -7.3931 | -7.5268 | 1.9630 | 0.2348 | 0.2348 | 5.1565 |
| Ispinesib | MDA-MB-453 | -4.4776 | 0.9397 | -7.4946 | -7.4292 | -7.5398 | 3.9990 | 0.2265 | 0.2265 | 5.3584 |
| Ispinesib | MDA-MB-468 | -4.4776 | 0.9803 | -7.7276 | -7.6985 | -7.7951 | 2.4010 | 0.0684 | 0.0684 | 4.1851 |
| Ispinesib | T47D | -4.4776 | 0.9250 | -6.5656 | -6.5271 | -7.0982 | 0.6992 | 0.0297 | 0.0623 | 5.7580 |